Moritz P Herle, Carol Kan, Kaushalya Jayaweera, Anushka Adikari, Sisira Siribaddana, Helena M S Zavos, Milana Smolkina, Athula Sumathipala, Clare Llewellyn, Khalida Ismail, Matthew Hotopf, Janet Treasure, Frühling Rijsdijk
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引用次数: 5
摘要
本研究利用遗传模型拟合分析，调查了斯里兰卡人群中情绪暴饮暴食(EOE)和抑郁症状的遗传和环境因素及其共变。在科伦坡双胞胎和单胞胎研究-第2阶段中，总共有3957名双胞胎和单胞胎对他们的EOE行为和抑郁症状进行了评分，这两者之间存在显著相关性(男性:r = 0.11, 95%可信区间(CI) 0.06-0.16，女性:r = 0.12, 95%可信区间(CI) 0.07-0.16)。非共享环境因素解释了男性的大部分差异(eoee2 = 87%， 95% CI 78-95%;抑郁症状e2 = 72%， 95% CI 61-83%)和女性(EOE e2 = 76%， 95% CI 68-83%;抑郁症状e2 = 64%， 95% CI 55-74%)。遗传因素对女性EOE的影响(h2 = 21%， 95% CI 4-32%)大于男性(h2 = 9%， 95% CI 0-20%)。共同环境因素对男性抑郁症状的影响(c2 = 25%， 95% CI 10-36%)大于女性(c2 = 9%， 95% CI 0-35%)。非共享的环境因素解释了女性抑郁症状和EOE之间的重叠，而不是男性。结果与高收入人群不同，这突出了在全球人群中进行行为遗传学研究的必要性。
The association between emotional eating and depressive symptoms: a population-based twin study in Sri Lanka.
This study investigated the genetic and environmental contributions to emotional overeating (EOE) and depressive symptoms, and their covariation, in a Sri-Lankan population, using genetic model-fitting analysis. In total, 3957 twins and singletons in the Colombo Twin and Singleton Study-Phase 2 rated their EOE behaviour and depressive symptoms, which were significantly associated (men: r = 0.11, 95% confidence interval (CI) 0.06-0.16, women: r = 0.12, 95% CI 0.07-0.16). Non-shared environmental factors explained the majority of variance in men (EOE e2 = 87%, 95% CI 78-95%; depressive symptoms e2 = 72%, 95% CI 61-83%) and women (EOE e2 = 76%, 95% CI 68-83%; depressive symptoms e2 = 64%, 95% CI 55-74%). Genetic factors were more important for EOE in women (h2 = 21%, 95% CI 4-32%) than men (h2 = 9%, 95% CI 0-20%). Shared-environmental factors were more important for depressive symptoms in men (c2 = 25%, 95% CI 10-36%) than women (c2 = 9%, 95% CI 0-35%). Non-shared environmental factors explained the overlap between depressive symptoms and EOE in women but not in men. Results differed from high-income populations, highlighting the need for behavioural genetic research in global populations.
期刊介绍：
Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance.
Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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