失忆性痴呆症与行为性痴呆症中与神经病理学相关的冷漠和抑制。

IF 2.7 4区医学 Q2 CLINICAL NEUROLOGY American Journal of Alzheimers Disease and Other Dementias Pub Date : 2019-08-01 Epub Date: 2019-06-06 DOI:10.1177/1533317519853466

Letizia G Borges, Alfred W Rademaker, Eileen H Bigio, M-Marsel Mesulam, Sandra Weintraub

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引用次数: 0

摘要

研究目的调查临床诊断为阿尔茨海默型痴呆（DAT）或行为变异型额颞叶痴呆（bvFTD）、神经病理学检查为阿尔茨海默病（AD）或额颞叶变性（FTLD）的患者的冷漠和抑制频率：对887例病例的回顾性数据进行了分析，并比较了4组病例在基线和纵向出现冷漠和抑制的频率：方法：分析了 887 例病例的回顾性数据，并比较了 4 组病例在基线和纵向的淡漠和抑制频率：DAT/AD、DAT/FTLD、bvFTD/FTLD 和 bvFTD/AD：结果：AD（33%）比 FTLD（25%）更常见于单纯的淡漠，而 FTLD（43%）比 AD（14%；P < .0001）更常见于淡漠和抑制的结合。随着时间的推移，随着痴呆症严重程度的增加，淡漠症在AD中变得更加常见（33%-41%；P < .006）：结论：阿尔茨海默病的神经病理学与神经精神症状淡漠的关系最为密切，而后天性痴呆症与淡漠和抑制的组合关系最为密切。随着时间的推移，AD 和 FTLD 神经病理学中出现淡漠的频率都在增加。

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Apathy and Disinhibition Related to Neuropathology in Amnestic Versus Behavioral Dementias.

Objectives: Investigating the frequency of apathy and disinhibition in patients clinically diagnosed with dementia of the Alzheimer type (DAT) or behavioral variant frontotemporal dementia (bvFTD) with neuropathology of either Alzheimer disease (AD) or frontotemporal lobar degeneration (FTLD).

Methods: Retrospective data from 887 cases were analyzed, and the frequencies of apathy and disinhibition were compared at baseline and longitudinally in 4 groups: DAT/AD, DAT/FTLD, bvFTD/FTLD, and bvFTD/AD.

Results: Apathy alone was more common in AD (33%) than FTLD (25%), and the combination of apathy and disinhibition was more common in FTLD (43%) than AD (14%; P < .0001). Over time, apathy became more frequent in AD with increasing dementia severity (33%-41%; P < .006).

Conclusions: Alzheimer disease neuropathology had the closest association with the neuropsychiatric symptom of apathy, while FTLD was most associated with the combination of apathy and disinhibition. Over time, the frequency of those with apathy increased in both AD and FTLD neuropathology.

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来源期刊

American Journal of Alzheimers Disease and Other Dementias GERIATRICS & GERONTOLOGY-CLINICAL NEUROLOGY

CiteScore

5.40

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： American Journal of Alzheimer''s Disease and other Dementias® (AJADD) is for professionals on the frontlines of Alzheimer''s care, dementia, and clinical depression--especially physicians, nurses, psychiatrists, administrators, and other healthcare specialists who manage patients with dementias and their families. This journal is a member of the Committee on Publication Ethics (COPE).