精神分裂症患者对抗精神病药物的态度:埃塞俄比亚亚的斯亚贝巴Amanuel精神专科医院的横断面研究

IF 3.6 Q1 PSYCHIATRY Schizophrenia Research and Treatment Pub Date : 2019-05-22 eCollection Date: 2019-01-01 DOI:10.1155/2019/5094017

Tilahun Kassew, Demeke Demilew, Addis Birhanu, Mesele Wonde, Biks Liyew, Shegaye Shumet

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引用次数: 10

摘要

背景:对抗精神病药物的不良态度很高，这是导致不坚持治疗的一个因素。这增加了复发的风险、相关的医疗保健利用和成本。本研究旨在评估精神分裂症患者对抗精神病药物的态度。目的:本基于机构的横断面研究旨在评估2018年在Amanuel精神专科医院门诊就诊的精神分裂症患者对抗精神病药物的态度及其相关因素。方法:采用系统随机抽样方法，对来自Amanuel精神专科医院的393例精神分裂症患者进行横断面研究。采用药物态度量表(DAI-10)评估患者对抗精神病药物的态度、经验和信念。采用改良版格拉斯哥抗精神病药物副作用量表、阳性和阴性症状量表、桦木精神病洞察力量表评估相关因素。拟合简单和多元线性回归分析模型，采用95%置信区间调整后的非标准化β (β)系数。结果:患者对抗精神病药物态度的平均得分为6.51分，标准差为2.22分。在多元线性回归中,阳性症状(β= -0.07,95%置信区间CI:(-0.09, -0.05),阴性症状(β= -0.04,95%置信区间CI:(-0.06, -0.02),(≤5年)持续时间短的疾病(β= -0.39,95%置信区间CI:(-0.63, -0.15),第一代抗精神病药物(β= -0.35,95%置信区间CI:(-0.55, -0.14)),有镇静(β= -0.28,95%置信区间CI:(-0.52, -0.02),和extra-pyramidal副作用(β= -0.34,95%置信区间CI:(-0.59, -0.09))是负面因素与态度有关抗精神病药物治疗。对疾病的认识(β= 0.24, 95% CI:(0.20, 0.27)与对抗精神病药物的态度呈正相关。结论:调查结果显示，被试对抗精神病药物的态度平均得分较好。预防副作用，特别是由于第一代抗精神病药物是必要的。

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Attitude towards Antipsychotic Medications in Patients Diagnosed with Schizophrenia: A Cross-Sectional Study at Amanuel Mental Specialized Hospital, Addis Ababa, Ethiopia.

Background: Poor attitude towards antipsychotic drugs is high, and it is a factor for non-adherence to treatment. This increases the risk of relapse, associated healthcare utilization, and costs. This study aimed to assess attitude towards antipsychotic medication among patients with schizophrenia.

Objectives: The aim of this institution based cross-sectional study was to assess attitude towards antipsychotic medications and associated factors among patients with schizophrenia who attend the outpatient clinics at Amanuel Mental Specialized Hospital, 2018.

Methods: In a cross-sectional study, 393 schizophrenic patients from Amanuel Mental Specialized Hospital were recruited by a systematic random sampling technique. Drug Attitude Inventory (DAI-10) was used to assess attitude, experience, and belief about antipsychotics. Glasgow antipsychotic side effect scale modified version, positive and negative syndrome scale, and Birch wood's insight scale for psychosis were the instruments used to assess the associated factors. Simple and multiple linear regression analysis models were fitted, and the adjusted unstandardized beta (β) coefficient at 95% confidence interval was used.

Results: The mean score of attitude towards antipsychotic medications was 6.51 with standard deviation (SD) of 2.22. In multiple linear regression, positive symptoms (β= -0.07, 95% CI: (-0.09, -0.05)), negative symptoms (β= -0.04, 95% CI: (-0.06,-0.02)), shorter (≤5 years) duration of illness (β= -0.39, 95% CI: (-0.63, -0.15)), first generation antipsychotics (β = -0.35, 95% CI: (-0.55,-0.14)), having sedation (β= -0.28, 95% CI: (-0.52, -0.02)), and extra-pyramidal side effects (β= -0.34, 95% CI: (-0.59,-0.09)) were factors negatively associated with attitude towards antipsychotic medication treatment. Insight to illness (β= 0.24, 95% CI: (0.20, 0.27) was a factor positively associated with attitude towards antipsychotic medications.

Conclusion: The result suggests that the mean score of participants' attitude towards antipsychotic medications was good. Prevention of side effects particularly due to first generation antipsychotics is necessary.

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来源期刊

Schizophrenia Research and Treatment PSYCHIATRY-

CiteScore

4.60

自引率

0.00%

发文量

审稿时长

14 weeks

期刊介绍： Schizophrenia Research and Treatment is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies related to all aspects of schizophrenia.