UCSC基因组浏览器:深度支持分子生物医学研究。

Mary E Mangan, Jennifer M Williams, Scott M Lathe, Donna Karolchik, Warren C Lathe
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引用次数: 22

摘要

基因组序列数据的数量和复杂性,以及注释基因组上下文所需的额外实验数据,对生物医学研究人员的显示和获取构成了重大挑战。基因组浏览器组织这些数据,并使其以各种方式可用,以提取有用的信息来推进研究项目。UCSC基因组浏览器就是这些资源之一。给定物种的官方序列数据形成了显示许多其他类型数据的框架,如表达、变异、跨物种比较等等。数据的可视化表示可用于探索。数据可以按顺序查询。使用Table Browser接口也可以轻松地实现复杂的数据库查询。相关工具允许附加查询类型或访问附加数据源,如原位定位图像。通过积极的讨论邮件列表和提供更新的培训材料,为解决研究人员的问题提供支持。UCSC基因组浏览器为广泛的生物医学分子研究提供了深度支持(http://genome.ucsc.edu)。
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UCSC genome browser: deep support for molecular biomedical research.

The volume and complexity of genomic sequence data, and the additional experimental data required for annotation of the genomic context, pose a major challenge for display and access for biomedical researchers. Genome browsers organize this data and make it available in various ways to extract useful information to advance research projects. The UCSC Genome Browser is one of these resources. The official sequence data for a given species forms the framework to display many other types of data such as expression, variation, cross-species comparisons, and more. Visual representations of the data are available for exploration. Data can be queried with sequences. Complex database queries are also easily achieved with the Table Browser interface. Associated tools permit additional query types or access to additional data sources such as images of in situ localizations. Support for solving researcher's issues is provided with active discussion mailing lists and by providing updated training materials. The UCSC Genome Browser provides a source of deep support for a wide range of biomedical molecular research (http://genome.ucsc.edu).

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