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引用次数: 0
摘要
最常见的白血病类型是急性髓性白血病(AML)，在所有白血病中生存率最低，尤其是在成人中。有证据表明，miRNA表达失调与AML有关。因此，本系统综述的目的是阐明miR-181a表达在AML中的作用。在本研究中，将包括miR-181a表达在AML患者中的作用的观察性研究。所有患者均应进行标准和指标检测。我们将检索PubMed, SCOPUS和ISI Web of Science，不受语言限制。结果将被审查miR-181a水平与AML进展之间的关联，并将研究这种与AML关系的强度。文章的选择和数据的提取将由两位独立的审稿人进行。STROBE将用于评估研究质量。发表偏倚和数据综合将通过漏斗图和Beggs和Egger使用Stata软件V.12.1的检验进行评估。伦理和传播没有伦理问题。本系统评价方案已在普洛斯彼罗(国际前瞻性系统评价注册)注册，注册号为CRD42016040080。
The relationship of miR-181a expression level and AML: A systematic review protocol
Introduction
The most common type of leukemia is acute myeloid leukemia (AML) with the lowest survival rate among all of the leukemias particularly in adults. The evidence has shown that dysregulation of miRNA expression is associated with AML. Therefore, the aim of this systematic review was to clarify the role of miR-181a expression in AML.
Methods and analysis
In the present study, observational studies of the roles of miR-181a expression in patients with AML will be included. Standards and indicators test should be performed for all patients. We will search PubMed, SCOPUS and ISI Web of Science with no restriction of language. The outcomes will be reviewed for association between miR-181a level and AML progression and the strength of this relationship with AML will be investigated. Selection of articles and data extraction will be performed by two independent reviewers. STROBE will be used for assessment of study quality. Publication bias and data synthesis will be an assessment by funnel plots and Beggs and Egger’s tests using Stata software V.12.1.
Ethics and dissemination
There are no ethical issues.
Trial registration number
This systematic review protocol is registered in the PROSPERO (International Prospective Register of Systematic Reviews), and registration number CRD42016040080.
期刊介绍：
IJS Protocols is the first peer-reviewed, international, open access journal seeking to publish research protocols across across the full breadth of the surgical field. We are aim to provide rapid submission to decision times whilst maintaining a high quality peer-review process.
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