Gabriela Trzewikoswki de Lima, Amanda Izeli Portilho, Elizabeth De Gaspari
{"title":"外膜囊泡免疫后与巴西乙型脑膜炎奈瑟菌的交叉反应性。","authors":"Gabriela Trzewikoswki de Lima, Amanda Izeli Portilho, Elizabeth De Gaspari","doi":"10.1177/2515135519894825","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Immunization against <i>Neisseria meningitidis</i> is important for public health. Vaccines composed of cross-reactivity antigens avoid strain-specific responses, ensuring more comprehensive protection.</p><p><strong>Methods: </strong>The cross-reactivity between three strains from the last outbreak of <i>N. meningitidis</i> in Brazil was assessed in our studies, using enzyme-linked immunosorbent assay (ELISA) and immunoblotting assays.</p><p><strong>Results: </strong>Both assays verifed a similar humoral response between the strains evaluated. Patterns of antigen recognition differed with each dose evaluated.</p><p><strong>Conclusions: </strong>We observed that immunization with <i>N. meningitidis</i> B outer membrane vesicles (OMVs) led to the production of antibodies that recognized antigens of heterologous strains, indicating possible protection against these evaluated strains.</p>","PeriodicalId":33285,"journal":{"name":"Therapeutic Advances in Vaccines and Immunotherapy","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2019-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/2515135519894825","citationCount":"5","resultStr":"{\"title\":\"Cross-reactivity with Brazilian strains of <i>Neisseria meningitidis</i> B after immunization with outer membrane vesicles.\",\"authors\":\"Gabriela Trzewikoswki de Lima, Amanda Izeli Portilho, Elizabeth De Gaspari\",\"doi\":\"10.1177/2515135519894825\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Immunization against <i>Neisseria meningitidis</i> is important for public health. Vaccines composed of cross-reactivity antigens avoid strain-specific responses, ensuring more comprehensive protection.</p><p><strong>Methods: </strong>The cross-reactivity between three strains from the last outbreak of <i>N. meningitidis</i> in Brazil was assessed in our studies, using enzyme-linked immunosorbent assay (ELISA) and immunoblotting assays.</p><p><strong>Results: </strong>Both assays verifed a similar humoral response between the strains evaluated. Patterns of antigen recognition differed with each dose evaluated.</p><p><strong>Conclusions: </strong>We observed that immunization with <i>N. meningitidis</i> B outer membrane vesicles (OMVs) led to the production of antibodies that recognized antigens of heterologous strains, indicating possible protection against these evaluated strains.</p>\",\"PeriodicalId\":33285,\"journal\":{\"name\":\"Therapeutic Advances in Vaccines and Immunotherapy\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2019-12-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1177/2515135519894825\",\"citationCount\":\"5\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Therapeutic Advances in Vaccines and Immunotherapy\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1177/2515135519894825\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2019/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"Medicine\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Therapeutic Advances in Vaccines and Immunotherapy","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1177/2515135519894825","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2019/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"Medicine","Score":null,"Total":0}
Cross-reactivity with Brazilian strains of Neisseria meningitidis B after immunization with outer membrane vesicles.
Background: Immunization against Neisseria meningitidis is important for public health. Vaccines composed of cross-reactivity antigens avoid strain-specific responses, ensuring more comprehensive protection.
Methods: The cross-reactivity between three strains from the last outbreak of N. meningitidis in Brazil was assessed in our studies, using enzyme-linked immunosorbent assay (ELISA) and immunoblotting assays.
Results: Both assays verifed a similar humoral response between the strains evaluated. Patterns of antigen recognition differed with each dose evaluated.
Conclusions: We observed that immunization with N. meningitidis B outer membrane vesicles (OMVs) led to the production of antibodies that recognized antigens of heterologous strains, indicating possible protection against these evaluated strains.
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