坏死下垂、肿瘤坏死和肿瘤发生。

IF 4.1 Q2 CELL BIOLOGY Cell Stress Pub Date : 2019-12-19 DOI:10.15698/cst2020.01.208
Zheng-Gang Liu, Delong Jiao
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引用次数: 69

摘要

坏死性上睑下垂,被称为程序性坏死,是一种不依赖半胱天酶的、精细调节的细胞死亡形式,具有坏死形态。肿瘤坏死,坏死细胞死亡灶,发生于晚期实体瘤,常与癌症患者预后不良相关。细胞凋亡在肿瘤消退中起着关键作用,细胞凋亡的失活是肿瘤发展的关键,但坏死下垂在肿瘤发生中的作用仍未完全了解,因为最近的研究报道了坏死下垂促进肿瘤和抑制肿瘤的作用。在这篇简短的综述中,我们将讨论一些关于坏死性上睑下垂在肿瘤发生中的作用的最新研究,并推测这些发现对未来研究和潜在的针对坏死性上睑下垂的新型癌症治疗的意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Necroptosis, tumor necrosis and tumorigenesis.

Necroptosis, known as programmed necrosis, is a form of caspase-independent, finely regulated cell death with necrotic morphology. Tumor necrosis, foci of necrotic cell death, occurs in advanced solid tumors and is often associated with poor prognosis of cancer patients. While it is well documented that apoptosis plays a key role in tumor regression and the inactivation of apoptosis is pivotal to tumor development, the role of necroptosis in tumorigenesis is still not fully understood as recent studies have reported both tumor-promoting and tumor-suppressing effects of necroptosis. In this short review, we will discuss some recent studies about the role of necroptosis in tumorigenesis and speculate the implications of these findings in future research and potential novel cancer therapy targeting necroptosis.

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来源期刊
Cell Stress
Cell Stress Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (miscellaneous)
CiteScore
13.50
自引率
0.00%
发文量
21
审稿时长
15 weeks
期刊介绍: Cell Stress is an open-access, peer-reviewed journal that is dedicated to publishing highly relevant research in the field of cellular pathology. The journal focuses on advancing our understanding of the molecular, mechanistic, phenotypic, and other critical aspects that underpin cellular dysfunction and disease. It specifically aims to foster cell biology research that is applicable to a range of significant human diseases, including neurodegenerative disorders, myopathies, mitochondriopathies, infectious diseases, cancer, and pathological aging. The scope of Cell Stress is broad, welcoming submissions that represent a spectrum of research from fundamental to translational and clinical studies. The journal is a valuable resource for scientists, educators, and policymakers worldwide, as well as for any individual with an interest in cellular pathology. It serves as a platform for the dissemination of research findings that are instrumental in the investigation, classification, diagnosis, and therapeutic management of major diseases. By being open-access, Cell Stress ensures that its content is freely available to a global audience, thereby promoting international scientific collaboration and accelerating the exchange of knowledge within the research community.
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