全球对线粒体替代技术的监管。

IF 7.7 2区 生物学 Q1 GENETICS & HEREDITY Annual review of genomics and human genetics Pub Date : 2020-08-31 Epub Date: 2020-01-21 DOI:10.1146/annurev-genom-111119-101815
I Glenn Cohen, Eli Y Adashi, Sara Gerke, César Palacios-González, Vardit Ravitsky
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引用次数: 18

摘要

线粒体替代技术(MRTs,也被称为线粒体替代疗法)给许多希望有基因相关的孩子但卵子中线粒体DNA突变的妇女带来了希望。mrt也引发了深刻的伦理分歧,并导致了全球不同的监管方法。在这篇综述中,我们讨论了几个国家对mrt的现行监管。在讨论了科学基础之后,我们描述了七个国家的现行法律和政策方向:英国、美国、加拿大、澳大利亚、德国、以色列和新加坡。我们还讨论了医疗旅游(也称为医疗旅行)的新兴现象,如mrt到希腊、西班牙、墨西哥和乌克兰等地。然后,我们得出了一些关于世界各地监管方法的异同的关键发现。
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The Regulation of Mitochondrial Replacement Techniques Around the World.

Mitochondrial replacement techniques (MRTs, also referred to as mitochondrial replacement therapies) have given hope to many women who wish to have genetically related children but have mitochondrial DNA mutations in their eggs. MRTs have also spurred deep ethical disagreements and led to different regulatory approaches worldwide. In this review, we discuss the current regulation of MRTs across several countries. After discussing the basics of the science, we describe the current law and policy directions in seven countries: the United Kingdom, the United States, Canada, Australia, Germany, Israel, and Singapore. We also discuss the emerging phenomenon of medical tourism (also called medical travel) for MRTs to places like Greece, Spain, Mexico, and Ukraine. We then pull out some key findings regarding similarities and differences in regulatory approaches around the world.

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来源期刊
CiteScore
14.90
自引率
1.10%
发文量
29
期刊介绍: Since its inception in 2000, the Annual Review of Genomics and Human Genetics has been dedicated to showcasing significant developments in genomics as they pertain to human genetics and the human genome. The journal emphasizes genomic technology, genome structure and function, genetic modification, human variation and population genetics, human evolution, and various aspects of human genetic diseases, including individualized medicine.
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