解决产科悖论:FETAL 技术--向无创评估胎儿 pH 值迈出的一步。

IF 3.2 Q1 OBSTETRICS & GYNECOLOGY Journal of Pregnancy Pub Date : 2020-02-08 eCollection Date: 2020-01-01 DOI:10.1155/2020/7801039
Jacques Balayla, Guy Shrem
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引用次数: 0

摘要

每年,在北美约 500 万名新生儿中,约有 85% 接受电子胎儿监护(EFM)评估。临床医生使用电子胎儿监护仪来评估胎儿氧合状态、胎儿健康状况和潜在的损害。尽管这项技术已得到广泛应用,但新生儿缺氧和酸中毒仍占足月新生儿发病率的很高比例。事实上,虽然胎儿的心律与胎儿的酸碱状态密不可分,但 EFM 并未被证明能可靠地预测新生儿的 pH 值状态,也未减少孕产妇或新生儿的不良结局。因此,EFM 预测新生儿不良结局的高假阳性率导致了阴道和剖宫产手术率的增加,同时也增加了相关孕产妇和新生儿的发病率。这一事实必然导致一个悖论,我们将其定义为 "产科悖论"。在本文中,我们探讨了解决这一悖论的潜在方法,并介绍了一种评估宫内胎儿酸碱状态的新型无创技术,即 "FETAL 技术"(傅立叶产程描记和酸中毒评估)。目前正在研究的 FETAL 技术将离散傅立叶变换应用于 EFM 曲线,以确定胎儿心率的频谱频率分布。这些特定的频率分布与特定的脐带 pH 值相关,并可能提供胎儿热率模式与出生时酸碱状态之间缺失的联系。当我们努力实现 EFM 的全部潜在益处时,找到实时评估胎儿 pH 值的最佳评估策略仍是产科的关键目标。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Solving the Obstetrical Paradox: The FETAL Technique-A Step toward Noninvasive Evaluation of Fetal pH.

Every year, about 85 percent of the approximately 5 million births in North America are evaluated with the electronic fetal monitoring (EFM). Clinicians use the EFM as a proxy to assess fetal oxygenation status, fetal well-being, and potential compromise. Despite the widespread use of this technology, neonatal hypoxia and acidosis continue to make up a high proportion of neonatal morbidity at term. Indeed, though the fetal heart rhythm is inextricably linked to fetal acid-base status, EFM has not been shown to reliably predict neonatal pH status nor has it reduced adverse maternal or neonatal outcomes. As a consequence, the high false-positive rate of EFM for predicting adverse neonatal outcomes has led to an increase in the rate of operative vaginal and cesarean delivery, with elevated rates of associated maternal and neonatal morbidity. This fact invariably leads to a paradox we have henceforth defined as the "obstetrical paradox." Herein, we explore the potential solutions to this paradox and introduce a novel noninvasive technique to assess fetal acid-base status in utero known as the "FETAL technique" (Fourier Evaluation of Tracings and Acidosis in Labour). The FETAL technique, currently under investigation, applies the discrete Fourier transformation to EFM tracings to determine the spectral frequency distribution of the fetal heart rate. These specific frequency distributions correlate with specific umbilical pH values and may provide the missing link between fetal heat rate patterns and acid-base status at birth. As we work toward realizing the full potential benefits of EFM, finding the best assessment strategies to evaluate fetal pH in real time remains a key goal in obstetrics.

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来源期刊
Journal of Pregnancy
Journal of Pregnancy OBSTETRICS & GYNECOLOGY-
CiteScore
6.10
自引率
0.00%
发文量
15
审稿时长
14 weeks
期刊介绍: Journal of Pregnancy is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies related to all aspects of pregnancy and childbirth. The journal welcomes submissions on breastfeeding, labor, maternal health and the biomedical aspects of pregnancy.
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