将慢性疾病和动脉粥样硬化的异质性概念化作为实现精准医疗的途径:内表型、内表型和残余心血管风险。

International Journal of Chronic Diseases Pub Date : 2020-02-12 eCollection Date: 2020-01-01 DOI:10.1155/2020/5950813
Vadim V Genkel, Igor I Shaposhnik
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引用次数: 0

摘要

文章讨论了医学科学各分支中病因异质性概念化的现代方法。文章探讨了内表型、内型和残余心血管风险的概念及其在内科和心脏病学中的应用范围。根据动脉粥样硬化遗传结构研究的最新成果,提出了五种动脉粥样硬化内型。所提出的每一种内型都代表了动脉粥样硬化发生的一种或另一种病理生理学机制,具有已确定的遗传基质、一组特征性生物标志物和一些临床特征。本文简要回顾了研究动脉粥样硬化内型的临床意义和前景。
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Conceptualization of Heterogeneity of Chronic Diseases and Atherosclerosis as a Pathway to Precision Medicine: Endophenotype, Endotype, and Residual Cardiovascular Risk.

The article discusses modern approaches to the conceptualization of pathogenetic heterogeneity in various branches of medical science. The concepts of endophenotype, endotype, and residual cardiovascular risk and the scope of their application in internal medicine and cardiology are considered. Based on the latest results of studies of the genetic architecture of atherosclerosis, five endotypes of atherosclerosis have been proposed. Each of the presented endotypes represents one or another pathophysiological mechanism of atherogenesis, having an established genetic substrate, a characteristic panel of biomarkers, and a number of clinical features. Clinical implications and perspectives for the study of endotypes of atherosclerosis are briefly reviewed.

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