溴域AAA+ atp酶形成形状。

Nucleus (Austin, Tex.) Pub Date : 2020-12-01 DOI:10.1080/19491034.2020.1741304

Magdalena Murawska, Andreas G Ladurner

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引用次数: 2

摘要

溴域AAA+ atp酶(与多种细胞活动相关的atp酶)正在成为致癌蛋白和抗癌治疗的引人注目的靶点。然而，对这些机器的结构和生物化学的洞察是缺失的。Cho等人最近的一项研究报告了溴域AAA+ atp酶的第一个低温电镜结构，并首次深入了解了这种假定的组蛋白伴侣的功能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Bromodomain AAA+ ATPases get into shape.

Bromodomain AAA+ ATPases (ATPases associated with diverse cellular activities) are emerging as oncogenic proteins and compelling targets for anticancer therapies. However, structural and biochemical insight into these machines is missing. A recent study by Cho et al. reports the first cryo-EM structure of a bromodomain AAA+ ATPase and provides first insights into the functions of this putative histone chaperone.

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Nucleus (Austin, Tex.)

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