Panagiota Bougatsou, Eirini-Kanella Panagiotopoulou, Maria Gkika, Doukas Dardabounis, Aristeidis Konstantinidis, Haris Sideroudi, Irfan Perente, Georgios Labiris
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引用次数: 7
摘要
背景:本研究的目的是探讨532 nm(绿色)二极管阈下微脉冲激光(SML)治疗非中心受病灶临床显著黄斑水肿(CSME)的效果，并与传统激光光凝(CLP)进行比较。方法:将诊断为非中心累及性CSME的患者60只眼随机分为两组。第一组采用SML光凝治疗(G1)，第二组采用CLP治疗(G2)。在治疗前和干预后3个月和6个月分别测量中央黄斑厚度(CMT)和最佳矫正视力(BCVA)。结果:与G2相比，G1参与者在激光应用后6个月的CMT明显更好(p = 0.04)。此外，两组患者在激光治疗后6个月的CMT均显著低于基线值(G1: p < 0.001, G2: p = 0.002)。此外，与激光治疗前相比，SML后6个月G1的BCVA有显著改善(p = 0.001)。结论:SML在降低CMT和改善BCVA方面比CLP更有效。因此，如果在未来的研究中得到证实，SML可以很好地替代CLP治疗DME。
Comparison of Subthreshold 532 nm Diode Micropulse Laser with Conventional Laser Photocoagulation in the Treatment of Non-Centre Involved Clinically Significant Diabetic Macular Edema.
Background: The aim of the study was to investigate the effect of the 532 nm (green) diode subthreshold micropulse laser (SML) in the treatment of non-centre involved clinically significant macular edema (CSME) in comparison to the conventional laser photocoagulation (CLP).
Methods: A total of 60 eyes of patients diagnosed with non-centre involved CSME were randomly divided into two groups. SML photocoagulation was performed in the first group (G1), while CLP in the second one (G2). Central macular thickness (CMT) and best corrected visual acuity (BCVA) were measured prior to treatment and at 3 and 6 months after intervention.
Results: G1 participants had significantly better CMT at 6 months after laser application (p = 0.04) compared to G2. Additionally, CMT in both groups was significantly lower 6 months after laser application in comparison to baseline values (G1: p < 0.001, G2: p = 0.002). Moreover, significant improvement was detected 6 months after SML in G1 regarding BCVA compared to values before laser treatment (p = 0.001).
Conclusion: SML was more effective than CLP in reducing CMT and improving BCVA in patients with non-centre involved CSME. Therefore, it seems that SML can be a good substitute for CLP in DME treatment if confirmed in future studies.
期刊介绍：
Acta Medica (Hradec Králové) is a multidisciplinary medical journal published by the Faculty of Medicine in Hradec Králové - Karolinum Press, the publishing house of Charles University. The journal is peer-reviewed and published quarterly in both paper and electronic form. The language of Acta Medica is English. Offerings include review articles, original articles, brief communications, case reports, announcements and notices. The journal was founded in 1958 under the title "A Collection of Scientific Works of the Charles University Faculty of Medicine in Hradec Kralove."
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