Toll样受体在口腔鳞状细胞癌进展和抑制中的作用。

IF 3.1 Q2 ONCOLOGY Oncology Reviews Pub Date : 2020-05-19 eCollection Date: 2020-02-18 DOI:10.4081/oncol.2020.456
Yash Sharma, Kumud Bala
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引用次数: 6

摘要

口腔鳞状细胞癌(Oral squamous cell carcinoma, OSCC)是头颈部鳞状细胞癌中最常见的一种,也是一种多因素的过程,它由吸烟、咀嚼和饮酒等改变细胞内环境的最重要因素组成。近年来的研究表明Toll样受体(TLR)与肿瘤发生有关。本综述旨在探讨TLR与OSCC进展和抑制的关系。这篇综述是一篇经典的综述,局限于过去19年(即2000-2019年)发表的文章,总结了作者的观点。我们回顾了62篇文章,发现OSCC的进展和抑制与不同的tlr促进肿瘤的发展和抑制口腔肿瘤的进展有关。我们发现,TLR2、TLR3、TLR4、TLR5、TLR7和TLR9与肿瘤发生有关,即与OSCC的进展有关,其中通过TLR3和TLR7抑制OSCC。我们的作者希望通过文献调查得出结论,表明TLR对OSCC的发展有效,并且可以探索在不久的将来用于治疗目的的其他TLR。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Role of Toll like receptor in progression and suppression of oral squamous cell carcinoma.

Oral squamous cell carcinoma (OSCC) is one of the most common type of head and neck squamous cell carcinoma and one of the multifactorial process that consists of most contributing factors such as tobacco smoking, chewing and alcohol consumption that altered the intracellular environment. Recent studies have shown relevance of Toll like receptor (TLR) associated with carcinogenesis. This review aim's to explore that how TLR associates with progression and suppression of OSCC. This review is a classical review that has confined to articles published in the past 19 years (i.e. 2000-2019) and has summarized the perspective of the authors. 62 articles were reviewed and it was found that progression and suppression of OSCC is associated with different TLRs promoting tumor development and also inhibiting the progression of oral neoplasm. It was found that TLR2, TLR3, TLR4, TLR5, TLR7 and TLR9 are associated with tumor development i.e. in progression of OSCC, where as suppression of OSCC through TLR3 and TLR7. We authors would like to conclude that literature survey has indicated effective TLR's against OSCC development and can be explored to investigate other TLRs that can be used for therapeutic purposes in near future.

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来源期刊
Oncology Reviews
Oncology Reviews ONCOLOGY-
CiteScore
6.30
自引率
0.00%
发文量
9
审稿时长
9 weeks
期刊介绍: Oncology Reviews is a quarterly peer-reviewed, international journal that publishes authoritative state-of-the-art reviews on preclinical and clinical aspects of oncology. The journal will provide up-to-date information on the latest achievements in different fields of oncology for both practising clinicians and basic researchers. Oncology Reviews aims at being international in scope and readership, as reflected also by its Editorial Board, gathering the world leading experts in both pre-clinical research and everyday clinical practice. The journal is open for publication of supplements, monothematic issues and for publishing abstracts of scientific meetings; conditions can be obtained from the Editor-in-Chief or the publisher.
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