不同透析膜在多发性骨髓瘤患者治疗中的应用。

Q3 Medicine Polimery w medycynie Pub Date : 2019-07-01 DOI:10.17219/pim/122014
Maciej Szymczak, Dorota Zielińska, Aleksandra Musiała
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引用次数: 0

摘要

游离轻链积聚是多发性骨髓瘤患者肾损伤的原因。游离轻链的去除可以改善患者的预后和生存,在某些情况下可以停止透析治疗。不幸的是,传统的透析在去除游离轻链方面不够有效。新的高截断(HCO)技术比传统透析更有效地去除游离轻链。在某些情况下,这种技术可能比血液滤过更好。然而,在去除kappa和lambda轻链的具体技术之间存在一些差异。在透析过程中,通过改变过滤器,聚甲基丙烯酸甲酯膜可以更好地去除Lambda轻链。聚甲基丙烯酸甲酯膜和HCO (35000 Da)聚砜膜可彻底去除Kappa轻链。不幸的是,很难区分HCO透析治疗和伴随化疗的效果,因为一些数据不是完全结论性的。对个别患者使用适当的技术可以获得最佳有效的治疗结果。
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The use of different dialysis membranes in therapy of patients with multiple myeloma.

Free light chains accumulation is the reason of kidney injury in patients with multiple myeloma. The removal of free light chains can improve patients prognosis and survival, and in some cases allows for dialysotherapy discontinuation. Unfortunately, conventional dialysis is not effective enough in terms of free light chains removal. New high cut-off (HCO) techniques remove free light chains more effectively than conventional dialysis. In some cases, this technique may turn out better than hemodiafiltration. However, there are some differences between specific techniques in the removal of kappa and lambda light chains. Lambda light chains are better removed by polymethyl methacrylate membranes with a change of filter during dialysis. Kappa light chains are thoroughly removed by polymethyl methacrylate membranes and HCO (35,000 Da) polysulfone membranes. Unfortunately, it is very difficult to differentiate between the effect of HCO dialysis therapy and concomitant chemotherapy because some of the data is not fully conclusive. Using the proper technique for an individual patient may give optimally effective treatment results.

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来源期刊
Polimery w medycynie
Polimery w medycynie Medicine-Medicine (all)
CiteScore
3.30
自引率
0.00%
发文量
9
审稿时长
53 weeks
期刊最新文献
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