Emily W Flanagan, Jasper Most, Jacob T Mey, Leanne M Redman
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Calorie restriction (CR), the reduction of dietary intake below energy requirements while maintaining optimal nutrition, is the only known nutritional intervention with the potential to attenuate aging. Evidence from observational, preclinical, and clinical trials suggests the ability to increase life span by 1-5 years with an improvement in health span and quality of life. CR moderates intrinsic processes of aging through cellular and metabolic adaptations and reducing risk for the development of many cardiometabolic diseases. Yet, implementation of CR may require unique considerations for the elderly and other specific populations. The objectives of this review are to summarize the evidence for CR to modify primary and secondary aging; present caveats for implementation in special populations; describe newer, alternative approaches that have comparative effectiveness and fewer deleterious effects; and provide thoughts on the future of this important field of study.
期刊介绍：
Annual Review of Nutrition
Publication History:In publication since 1981
Scope:Covers significant developments in the field of nutrition
Topics Covered Include:
Energy metabolism;
Carbohydrates;
Lipids;
Proteins and amino acids;
Vitamins;
Minerals;
Nutrient transport and function;
Metabolic regulation;
Nutritional genomics;
Molecular and cell biology;
Clinical nutrition;
Comparative nutrition;
Nutritional anthropology;
Nutritional toxicology;
Nutritional microbiology;
Epidemiology;
Public health nutrition
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