比较四份描述肾上腺素净化的文件,以及三位重要科学家,上中圭三,永井永吉和高胺佐一的工作

Q3 Arts and Humanities Journal of Anesthesia History Pub Date : 2020-06-01 DOI:10.1016/j.janh.2020.04.001
Rie Mieda, Chizu Aso, Tadanao Hiroki, Masafumi Kanamoto, Takashi Suto, Masaru Tobe, Shigeru Saito
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引用次数: 1

摘要

上中圭三的名字在教科书中没有记载。然而,上中是研究麻黄碱的科学家,在肾上腺素的纯化和结晶方面发挥了实际作用。他手写的备忘录《关于肾上腺素,备忘录,1900年7月至12月》现在保存在日本纳西夫的一座佛教寺庙——京佑寺。在本报告中,我们比较了Uenaka的原始描述和Jokichi Takamine发表的科学报告,并研究了四个文件中的每个陈述在成功的肾上腺素结晶方面是如何相互关联的。上中的备忘录包含了成功提纯的精确程序和实验提示。1901年,Takamine在《美国药学杂志》(The American Journal of Pharmacy)上发表了第一篇论文,并在1901年的《生理学杂志》(Journal of Physiology)上进行了总结。1903年,翻译1901年发表在《美国药学杂志》上的英文论文,在《yakugakuzashi》上发表了日文译本。读着上田中的备忘录,我们意识到他孜孜不倦地、孜孜不倦地进行着日常的实验,而这些实验对我们中的一些人来说可能是无聊和费力的。虽然上中的名字在世界上并不出名,但他是真正从事肾上腺素净化工作的主要科学家。
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Comparison of four documents describing adrenaline purification, and the work of three important scientists, Keizo Uenaka, Nagai Nagayoshi and Jokichi Takamine

The name of Keizo Uenaka has not been documented in textbooks. However, Uenaka was the scientist who worked on ephedrine and played a practical role in the purification and crystallization of adrenaline. His handwritten memorandum, “On Adrenaline, Memorandum, July to December, 1900” is now stored in a Buddhist temple, Kyougyou-ji in Nashio, Japan.

In the present report, we compared Uenaka's original description and Jokichi Takamine's published scientific reports, and examined how each statement in four documents are related to each other in terms of successful adrenaline crystallization.

Uenaka's memorandum contained precise procedures and experimental tips for successful purification. The experimental steps were considered to transcribed in the first published document in The American Journal of Pharmacy by Takamine in 1901, and summarized in another document in ``Journal of Physiology'' in 1901. A Japanese version was published in ``Yakugakuzasshi'' in 1903 by translating the English paper in the American Journal of Pharmacy published in 1901.

Reading Uenaka's memorandum, we realized that he tirelessly and diligently undertook routine experiments that to some of us might seem boring and laborious. Although the name of Uenaka is not globally well known, he was the main scientist who did the actual work of purifying adrenaline.

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Journal of Anesthesia History
Journal of Anesthesia History Arts and Humanities-History and Philosophy of Science
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期刊介绍: The Journal of Anesthesia History (ISSN 2352-4529) is an international peer-reviewed journal dedicated to advancing the study of anesthesia history and related disciplines. The Journal addresses anesthesia history from antiquity to the present. Its wide scope includes the history of perioperative care, pain medicine, critical care medicine, physician and nurse practices of anesthesia, equipment, drugs, and prominent individuals. The Journal serves a diverse audience of physicians, nurses, dentists, clinicians, historians, educators, researchers and academicians.
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