双侧脉膜新生血管膜伴静止型Vogt-Koyanagi-Harada综合征1例玻璃体内注射阿布西普治疗临床效果良好。

GMS ophthalmology cases Pub Date : 2020-04-17 eCollection Date: 2020-01-01 DOI:10.3205/oc000150
Sefik Can Ipek, Ziya Ayhan, Sinan Emre, Ali Osman Saatci
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引用次数: 4

摘要

目的:探讨双侧玻璃体腔内注射阿布西普治疗双侧脉络膜新生血管膜伴静止型Vogt-Koyanagi-Harada综合征的临床疗效。病例报告:一名30岁妇女在另一机构被诊断为VKH综合征,并口服霉酚酸酯两年缓解。然而,在初次诊断两年后,几乎同时发现右侧中央凹旁和左侧中央凹下2型脉络膜新生血管膜。在8个月内,右眼(OD)接受了3次注射,左眼(OS)接受了4次注射。最后一次随访时,OD视力为20/30,OS视力为20/25。结论:虽然炎症型脉络膜新生血管膜必须抑制炎症,但抗vegf(血管内皮生长因子)药物治疗是关键的治疗辅助手段,如本病例中的阿布西普,可能有助于改善视力预后。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Favorable clinical outcome with intravitreal aflibercept treatment in a case with bilateral choroidal neovascular membrane and quiescent Vogt-Koyanagi-Harada syndrome.

Objective: To describe the favorable clinical outcome in a case with bilateral choroidal neovascular membrane and quiescent Vogt-Koyanagi-Harada (VKH) syndrome by administering bilateral intravitreal aflibercept injections. Case report: A 30-year-old woman was diagnosed with VKH syndrome at another institution and had been in remission with oral mycophenolate mofetil for two years. However, nearly simultaneous right juxtafoveal and left subfoveal type 2 choroidal neovascular membrane was detected two years after the initial diagnosis. The right eye (OD) received three and the left eye (OS) received four aflibercept injections within a time span of eight months. Visual acuity was 20/30 in OD and 20/25 in OS at the last follow-up visit. Conclusion: Although suppression of inflammation is a must in eyes with inflammatory type choroidal neovascular membranes, anti-VEGF (vascular endothelial growth factor) therapy with agents, such as aflibercept in the present case, is a key therapeutic adjunct and may possibly help improve the visual prognosis.

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