酒石酸溴硝定和马来酸噻莫洛尔滴眼液对早产儿中枢神经系统和呼吸功能的影响。

GMS ophthalmology cases Pub Date : 2020-05-04 eCollection Date: 2020-01-01 DOI:10.3205/oc000152
Corrina P Azarcon, Darby E Santiago
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引用次数: 1

摘要

目的:我们报告了3例早产儿在不小心接触0.2%酒石酸溴硝定和0.5%马来酸噻莫洛尔固定联合滴眼液后出现中枢神经系统(CNS)和呼吸抑制的病例。病例描述:3例新生儿在给予0.2%酒石酸溴硝定和0.5%马来酸噻莫洛尔滴眼液2小时内出现中枢神经系统和呼吸抑制。新生儿重症监护病房(NICU)入院时开始进行呼吸支持。联合用药作用持续24 ~ 48小时。结论:本病例提示酒石酸溴莫那定与马来酸噻莫洛尔联用可引起早产儿中枢神经和呼吸系统的长期抑制。
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Prolonged central nervous system and respiratory depression in preterm neonates after exposure to brimonidine tartrate and timolol maleate ophthalmic drops.

Objective: We report three cases of preterm neonates who presented with central nervous system (CNS) and respiratory depression after inadvertent exposure to brimonidine tartrate 0.2% and timolol maleate 0.5% fixed-combination ophthalmic drops. Case descriptions: CNS and respiratory depression were observed in the three neonates within two hours of administration of brimonidine tartrate 0.2% and timolol maleate 0.5% eye drops. Respiratory support was initiated upon admission to the neonatal intensive care unit (NICU). The effects of the drug combination lasted for 24 to 48 hours. Conclusion: This case series suggests that the drug combination of brimonidine tartrate and timolol maleate causes a prolonged depression of the central nervous and respiratory systems in preterm neonates.

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