芬太尼对美托咪定-美沙酮预处理犬眼压和瞳孔大小的影响:一项试验研究。

IF 1.3 Q2 VETERINARY SCIENCES Veterinary Record Open Pub Date : 2020-07-28 eCollection Date: 2020-01-01 DOI:10.1136/vetreco-2019-000391
Maria Isabel Gomez-Martinez, Oscar Varela-Lopez, Jose Luis Fontalba-Navas, Antonio González-Cantalapiedra
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引用次数: 0

摘要

背景:这是一项试验性研究,旨在评估芬太尼对预先服用美托咪定和美沙酮的狗的眼压(IOP)和瞳孔大小(PS)的影响:这是一项试验性研究,旨在评估芬太尼对预先服用美托咪定和美沙酮的狗的眼压(IOP)和瞳孔大小(PS)的影响:方法:16 只犬的中位数(第一四分位数-第三四分位数)年龄为 3.5(1.25-6)岁,平均(sd)体重为 18.6(9.2)千克。在对所有狗肌肉注射美托咪啶(10 µg/kg)和美沙酮(0.5 mg/kg)进行预处理之前,记录了眼压和PS的基线读数。15 分钟和 30 分钟后重复这两项测量。之后,这些狗被随机分为两组。芬太尼组静脉注射芬太尼(10 µg/kg),对照组静脉注射相同剂量的生理盐水。两组分别在静脉注射后 1 分钟、5 分钟和 10 分钟测量并记录眼压和 PS 值。数据采用单向和双向重复测量方差分析或非参数等效分析:结果:肌肉注射预处理后 15 分钟和 30 分钟,PS 明显下降,而芬太尼组在静脉注射后所有时间点的眼压均明显升高:结论:不建议将美托咪定、美沙酮和芬太尼组合用于眼压升高或PS下降不理想的患者。
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Effects of fentanyl on intraocular pressure and pupil size in medetomidine-methadone premedicated dogs: a pilot study.

Background: This is a pilot study to evaluate the effects of fentanyl on intraocular pressure (IOP) and pupil size (PS) in dogs premedicated with medetomidine and methadone.

Methods: Sixteen dogs with a median (first quartile-third quartile) age of 3.5 (1.25-6) years and a mean (sd) weight of 18.6 (9.2) kg were included. Baseline readings of IOP and PS were recorded before all dogs were premedicated intramuscularly with medetomidine (10 µg/kg) and methadone (0.5 mg/kg). Both measurements were repeated 15 and 30 minutes later. Following this, the dogs were randomly assigned into two groups. The fentanyl group received intravenous fentanyl (10 µg/kg), while the control group received the same volume of saline solution intravenously. IOP and PS measurements were measured and recorded in both groups at one, five and ten minutes after intravenous injection. Data were analysed with one-way and two-way repeated-measures analysis of variance or their non-parametric equivalents.

Results: PS was significantly decreased 15 and 30 minutes following intramuscular premedication and IOP was significantly increased in the fentanyl group at all time points following intravenous administration.

Conclusions: Medetomidine, methadone and fentanyl combinations are not recommended for use in patients where an increase in IOP or decrease in PS is undesirable.

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来源期刊
Veterinary Record Open
Veterinary Record Open VETERINARY SCIENCES-
CiteScore
3.00
自引率
0.00%
发文量
25
审稿时长
19 weeks
期刊介绍: Veterinary Record Open is a journal dedicated to publishing specialist veterinary research across a range of topic areas including those of a more niche and specialist nature to that considered in the weekly Vet Record. Research from all disciplines of veterinary interest will be considered. It is an Open Access journal of the British Veterinary Association.
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