组蛋白变异:发育决定和表观遗传记忆的关系。

IF 8.7 1区 生物学 Q1 GENETICS & HEREDITY Annual review of genetics Pub Date : 2020-11-23 Epub Date: 2020-08-28 DOI:10.1146/annurev-genet-022620-100039
Benjamin Loppin, Frédéric Berger
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引用次数: 28

摘要

核小体动力学和性质是所有形式的基因组活动的核心。在核心组蛋白中,H3变体在调节核小体结构和功能方面起着关键作用。在这里,我们关注H3变异对发育各个方面的影响。DNA复制后复制H3变体的沉积对于转录后修饰编码的表观基因组信息的传递至关重要。通过这一过程,复制型H3维持了细胞的命运,而替代型H3.3变体则在早期胚胎发生时阻碍细胞分化。在发育的后期,H3.3和特殊的H3变体作为终末细胞分化(包括神经元和配子)的新的重要调节因子出现。调节H3.3沉积动力学的特定途径在驱动合子激活和启动新发育周期的重编程事件中至关重要。
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Histone Variants: The Nexus of Developmental Decisions and Epigenetic Memory.

Nucleosome dynamics and properties are central to all forms of genomic activities. Among the core histones, H3 variants play a pivotal role in modulating nucleosome structure and function. Here, we focus on the impact of H3 variants on various facets of development. The deposition of the replicative H3 variant following DNA replication is essential for the transmission of the epigenomic information encoded in posttranscriptional modifications. Through this process, replicative H3 maintains cell fate while, in contrast, the replacement H3.3 variant opposes cell differentiation during early embryogenesis. In later steps of development, H3.3 and specialized H3 variants are emerging as new, important regulators of terminal cell differentiation, including neurons and gametes. The specific pathways that regulate the dynamics of the deposition of H3.3 are paramount during reprogramming events that drive zygotic activation and the initiation of a new cycle of development.

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来源期刊
Annual review of genetics
Annual review of genetics 生物-遗传学
CiteScore
18.30
自引率
0.90%
发文量
17
期刊介绍: The Annual Review of Genetics, published since 1967, comprehensively covers significant advancements in genetics. It encompasses various areas such as biochemical, behavioral, cell, and developmental genetics, evolutionary and population genetics, chromosome structure and transmission, gene function and expression, mutation and repair, genomics, immunogenetics, and other topics related to the genetics of viruses, bacteria, fungi, plants, animals, and humans.
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