伴有细胞外黏蛋白和 HER2 扩增的乳腺多形性浸润性小叶癌

IF 1.8 Q3 ONCOLOGY Breast Cancer : Basic and Clinical Research Pub Date : 2020-11-24 eCollection Date: 2020-01-01 DOI:10.1177/1178223420976383
Matthew J Burky, Emily M Ray, David W Ollila, Siobhan M O'Connor, Johann D Hertel, Benjamin C Calhoun
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引用次数: 0

摘要

伴有细胞外粘蛋白的浸润性小叶癌是一种不常见的浸润性乳腺癌。世界卫生组织第五版《乳腺肿瘤分类》指出,这类肿瘤是粘液癌还是浸润性小叶癌的一种亚型尚不清楚。伴有细胞外粘液的浸润性小叶癌常表现为可触及的肿块,与典型的浸润性小叶癌相比,更有可能为 2 至 3 级和 HER2 阳性。这例多形性浸润性小叶癌伴有细胞外粘液蛋白,仅通过影像学检查发现,且HER2-扩增,这表明此类肿瘤中的一部分可能临床隐匿,但具有侵袭性表型。带有细胞外粘蛋白的浸润性小叶癌并不常见,了解这种肿瘤有助于避免误诊。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Pleomorphic Invasive Lobular Carcinoma of the Breast With Extracellular Mucin and HER2 Amplification.

Invasive lobular carcinoma with extracellular mucin is an uncommon pattern of invasive breast carcinoma. The 5th Edition of the World Health Organization Classification of Breast Tumors states that it is unknown whether these tumors are a subtype of mucinous carcinoma or invasive lobular carcinoma. Invasive lobular carcinoma with extracellular mucin frequently presents as a palpable mass and may be more likely to be grade 2 to 3 and HER2-positive than classic invasive lobular carcinoma. This case of pleomorphic invasive lobular carcinoma with extracellular mucin was detected by imaging only and was HER2-amplified, suggesting that a subset of these tumors may be clinically occult with an aggressive phenotype. Invasive lobular carcinoma with extracellular mucin is infrequently encountered and awareness of this entity is helpful in avoiding misdiagnosis.

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来源期刊
CiteScore
5.10
自引率
3.40%
发文量
22
审稿时长
8 weeks
期刊介绍: Breast Cancer: Basic and Clinical Research is an international, open access, peer-reviewed, journal which considers manuscripts on all areas of breast cancer research and treatment. We welcome original research, short notes, case studies and review articles related to breast cancer-related research. Specific areas of interest include, but are not limited to, breast cancer sub types, pathobiology, metastasis, genetics and epigenetics, mammary gland biology, breast cancer models, prevention, detection, therapy and clinical interventions, and epidemiology and population genetics.
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