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引用次数: 28
摘要
近年来，康复运动疗法已被描述为克服帕金森病常规治疗方法局限性的重要方法。本研究旨在评价运动疗法治疗帕金森病的疗效和安全性。截至2016年12月，评估帕金森病患者运动疗法的随机对照试验在五个电子数据库中进行了检索:PubMed、CENTRAL、EMBASE、OASIS和CNKI。纳入了18项研究(1144例患者)。总体的方法学质量不高。与接受非运动治疗的患者相比，接受运动治疗的患者在UPDRS总分、UPDRS II和III、Berg平衡量表、首选步行速度和Timed Up and Go测试方面表现出统计学上显著的改善。与进行常规活动的患者相比，接受运动疗法的患者在UPDRS、UPDRS II和UPDRS III的总水平上表现出统计学上显著的改善。研究发现，运动疗法相对安全。运动疗法可能促进帕金森病运动症状的改善。然而，由于随机对照试验数量较少和方法的局限性，我们无法得出具体的结论。因此，需要进一步的研究和更好的设计。
Exercise Therapies for Parkinson's Disease: A Systematic Review and Meta-Analysis.
Recently, rehabilitative exercise therapies have been described as an important method of overcoming the limitations of the conventional therapies for Parkinson's disease. The present study aimed to evaluate efficacy and safety of exercise therapies for Parkinson's disease. Randomized controlled trials that evaluated exercise therapies in patients with Parkinson's disease until December 2016 were searched for in five electronic databases: PubMed, CENTRAL, EMBASE, OASIS, and CNKI. Eighteen studies (1,144 patients) were included. The overall methodological quality was not high. Patients who underwent exercise therapies exhibited statistically significant improvements in the total UPDRS, UPDRS II and III, Berg Balance Scale, preferred walking speed, and Timed Up and Go Test compared to patients who underwent nonexercise therapies. In comparison to patients who performed regular activity, patients who underwent exercise therapies exhibited statistically significant improvements in the total UPDRS, UPDRS II, and UPDRS III. Exercise therapies were found to be relatively safe. Exercise therapies might promote improvements in the motor symptoms of Parkinson's disease. However, due to the small number of randomized controlled trials and methodological limitations, we are unable to draw concrete conclusions. Therefore, further studies with better designs will be needed.
期刊介绍：
Parkinson’s Disease is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies related to the epidemiology, etiology, pathogenesis, genetics, cellular, molecular and neurophysiology, as well as the diagnosis and treatment of Parkinson’s disease.
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