Justine R Horne, Jason Gilliland, Tara Leckie, Colleen O'Connor, Jamie A Seabrook, Janet Madill
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Participants (n = 140) completed a 7-day PA recall at baseline, 3, 6, and 12 months. Data from the PA recalls were used to calculate metabolic equivalents (METs), a measure of energy expenditure. Statistical analyses included split plot analyses of covariance and binary logistic regression (generalized linear models). Differences in leisure time PA weekly METs, weekly minutes of moderate + high-intensity PA, and adherence to PA guidelines were compared between groups (GLB and GLB + LGx) across the 4 time points.</p><p><strong>Results: </strong>Weekly METs were significantly higher in the GLB + LGx group (1,114.7 ± 141.9; 95% CI 831.5-1,397.8) compared to the standard GLB group (621.6 ± 141.9 MET/week; 95% CI 338.4-904.8) at the 6-month follow-up (p = 0.01). All other results were non-significant.</p><p><strong>Conclusions: </strong>The provision of an LGx intervention resulted in a greater weekly leisure time PA energy expenditure after the 6-month follow-up. 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引用次数: 2
摘要
背景:生活方式基因组学(LGx)是一门探索遗传变异、生活方式成分(如体力活动(PA))以及随后的健康和表现相关结果之间相互作用的科学。本研究的目的是确定LGx干预是否能比基于人群的干预更大程度地促进PA的参与。方法:在这个实用的随机对照试验中,参与者接受了标准的、基于人群的群体生活方式平衡(GLB)计划干预,或者GLB计划除了提供LGx信息和建议(GLB + LGx)。参与者(n = 140)在基线、3、6和12个月完成了为期7天的PA回忆。来自PA召回的数据用于计算代谢当量(METs),这是一种能量消耗的测量方法。统计分析包括协方差的分割图分析和二元逻辑回归(广义线性模型)。在4个时间点上比较各组(GLB组和GLB + LGx组)之间的休闲时间PA每周met、每周中+高强度PA分钟数和对PA指南的依从性的差异。结果:GLB + LGx组每周met显著高于对照组(1,114.7±141.9;95% CI 831.5- 1397.8)与标准GLB组(621.6±141.9 MET/周;95% CI 338.4-904.8),随访6个月(p = 0.01)。其他结果均无统计学意义。结论:在6个月的随访后,提供LGx干预导致每周休闲时间PA能量消耗增加。未来的研究应该确定这种情况如何才能长期维持下去。临床试验注册:NCT03015012。
Can a Lifestyle Genomics Intervention Motivate Patients to Engage in Greater Physical Activity than a Population-Based Intervention? Results from the NOW Randomized Controlled Trial.
Background: Lifestyle genomics (LGx) is a science that explores interactions between genetic variation, lifestyle components such as physical activity (PA), and subsequent health- and performance-related outcomes. The objective of this study was to determine whether an LGx intervention could motivate enhanced engagement in PA to a greater extent than a population-based intervention.
Methods: In this pragmatic randomized controlled trial, participants received either the standard, population-based Group Lifestyle BalanceTM (GLB) program intervention or the GLB program in addition to the provision of LGx information and advice (GLB + LGx). Participants (n = 140) completed a 7-day PA recall at baseline, 3, 6, and 12 months. Data from the PA recalls were used to calculate metabolic equivalents (METs), a measure of energy expenditure. Statistical analyses included split plot analyses of covariance and binary logistic regression (generalized linear models). Differences in leisure time PA weekly METs, weekly minutes of moderate + high-intensity PA, and adherence to PA guidelines were compared between groups (GLB and GLB + LGx) across the 4 time points.
Results: Weekly METs were significantly higher in the GLB + LGx group (1,114.7 ± 141.9; 95% CI 831.5-1,397.8) compared to the standard GLB group (621.6 ± 141.9 MET/week; 95% CI 338.4-904.8) at the 6-month follow-up (p = 0.01). All other results were non-significant.
Conclusions: The provision of an LGx intervention resulted in a greater weekly leisure time PA energy expenditure after the 6-month follow-up. Future research should determine how this could be sustained over the long-term.
期刊介绍:
Lifestyle Genomics aims to provide a forum for highlighting new advances in the broad area of lifestyle-gene interactions and their influence on health and disease. The journal welcomes novel contributions that investigate how genetics may influence a person’s response to lifestyle factors, such as diet and nutrition, natural health products, physical activity, and sleep, amongst others. Additionally, contributions examining how lifestyle factors influence the expression/abundance of genes, proteins and metabolites in cell and animal models as well as in humans are also of interest. The journal will publish high-quality original research papers, brief research communications, reviews outlining timely advances in the field, and brief research methods pertaining to lifestyle genomics. It will also include a unique section under the heading “Market Place” presenting articles of companies active in the area of lifestyle genomics. Research articles will undergo rigorous scientific as well as statistical/bioinformatic review to ensure excellence.