Angeles C Tecalco-Cruz, Josué O Ramírez-Jarquín, María E Alvarez-Sánchez, Jesus Zepeda-Cervantes
{"title":"阿尔茨海默病的表观遗传学基础。","authors":"Angeles C Tecalco-Cruz, Josué O Ramírez-Jarquín, María E Alvarez-Sánchez, Jesus Zepeda-Cervantes","doi":"10.4331/wjbc.v11.i2.62","DOIUrl":null,"url":null,"abstract":"<p><p>Alzheimer disease (AD) is the primary form of dementia that occurs spontaneously in older adults. Interestingly, the epigenetic profile of the cells forming the central nervous system changes during aging and may contribute to the progression of some neurodegenerative diseases such as AD. In this review, we present general insights into relevant epigenetic mechanisms and their relationship with aging and AD. The data suggest that some epigenetic changes during aging could be utilized as biomarkers and target molecules for the prevention and control of AD.</p>","PeriodicalId":23691,"journal":{"name":"World journal of biological chemistry","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2020-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/13/6b/WJBC-11-62.PMC7520642.pdf","citationCount":"0","resultStr":"{\"title\":\"Epigenetic basis of Alzheimer disease.\",\"authors\":\"Angeles C Tecalco-Cruz, Josué O Ramírez-Jarquín, María E Alvarez-Sánchez, Jesus Zepeda-Cervantes\",\"doi\":\"10.4331/wjbc.v11.i2.62\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Alzheimer disease (AD) is the primary form of dementia that occurs spontaneously in older adults. Interestingly, the epigenetic profile of the cells forming the central nervous system changes during aging and may contribute to the progression of some neurodegenerative diseases such as AD. In this review, we present general insights into relevant epigenetic mechanisms and their relationship with aging and AD. The data suggest that some epigenetic changes during aging could be utilized as biomarkers and target molecules for the prevention and control of AD.</p>\",\"PeriodicalId\":23691,\"journal\":{\"name\":\"World journal of biological chemistry\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2020-09-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/13/6b/WJBC-11-62.PMC7520642.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"World journal of biological chemistry\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4331/wjbc.v11.i2.62\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"World journal of biological chemistry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4331/wjbc.v11.i2.62","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Alzheimer disease (AD) is the primary form of dementia that occurs spontaneously in older adults. Interestingly, the epigenetic profile of the cells forming the central nervous system changes during aging and may contribute to the progression of some neurodegenerative diseases such as AD. In this review, we present general insights into relevant epigenetic mechanisms and their relationship with aging and AD. The data suggest that some epigenetic changes during aging could be utilized as biomarkers and target molecules for the prevention and control of AD.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
