代谢不健康表型与ADIPOQ遗传变异和低血清脂联素水平相关

IF 2 4区 医学 Q3 GENETICS & HEREDITY Lifestyle Genomics Pub Date : 2020-01-01 Epub Date: 2020-11-02 DOI:10.1159/000510021
Nathaly Torres-Castillo, Wendy Campos-Perez, Roberto Rodriguez-Echevarria, Sarai Citlalic Rodriguez-Reyes, Erika Martinez-Lopez
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引用次数: 6

摘要

背景:尽管过多的脂肪组织与慢性代谢紊乱有关,但并非所有超重(EW)的受试者都表现出代谢改变,也并非所有正常体重(NW)的受试者都具有代谢健康(MH)表型,这可能是由于基因-环境相互作用所致。本研究的目的是探讨ADIPOQ和PPARG遗传变异在不同代谢表型的NW和EW个体中的相互作用。方法:对墨西哥西部345名成年人的资料进行分析。根据体重指数将个体分为NW组和EW组,根据稳态模型评估胰岛素抵抗(HOMA-IR)和国家胆固醇教育计划成人治疗小组III (NCEP-ATP III)的葡萄糖、甘油三酯、高密度脂蛋白胆固醇和血压的截止点,将个体分类为MH或代谢不健康(MUH)。将参数改变≤1个的受试者归为MH。采用等位基因判别法分析ADIPOQ基因-11377C>G、-11391G>A、+45T>G、+276G>T的单核苷酸多态性(snp)和ppparg基因Pro12Ala的单核苷酸多态性。ELISA法检测高分子量脂联素异构体水平。结果:较低的血清脂联素水平与EW受试者的MUH表型相关。带有+45T>G SNP的GG或TG基因型的NW受试者发生MUH表型的几率降低。在ADIPOQ -11391G>A和-11377C>G snp位点上携带两个GG单倍型拷贝的个体血清脂联素水平低于零拷贝的个体。结论:在该人群中,EW-MUH表型的血清脂联素水平较低,NW-MH与EW-MH表型之间无差异。此外,+45T>G SNP与MUH表型的几率降低有关。
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A Metabolically Unhealthy Phenotype Is Associated with ADIPOQ Genetic Variants and Lower Serum Adiponectin Levels.

Background: Even though excessive adipose tissue is related to chronic metabolic disturbances, not all subjects with excess weight (EW) display metabolic alterations, and not all normal-weight (NW) subjects have a metabolically healthy (MH) phenotype, probably due to gene-environment interactions. The aim of this study was to investigate the interaction effects of ADIPOQ and PPARG genetic variants in NW and EW individuals with different metabolic phenotypes.

Methods: Data on 345 adults from western Mexico were analyzed. The individuals were classified into NW and EW groups according to body mass index, and were categorized as MH or metabolically unhealthy (MUH), considering homeostatic model assessment insulin resistance (HOMA-IR) and National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP III) cut-off points for glucose, triglycerides, high-density lipoprotein cholesterol, and blood pressure. Subjects with ≤1 altered parameter were classified as MH. The single nucleotide polymorphisms (SNPs) -11377C>G, -11391G>A, +45T>G, and +276G>T for ADIPOQ and Pro12Ala for PPARG were analyzed by allelic discrimination. High-molecular-weight adiponectin isoform levels were measured by ELISA.

Results: Lower serum adiponectin levels were associated with the MUH phenotype in EW subjects. NW subjects with the GG or TG genotype for the +45T>G SNP had reduced odds of the MUH phenotype. Individuals who carried two copies of the GG haplotype at the -11391G>A and -11377C>G SNPs for ADIPOQ had lower serum adiponectin levels than those with zero copies.

Conclusion: In this population, lower serum adiponectin levels were found in the EW-MUH phenotype, and no differences were observed between the NW-MH and the EW-MH phenotype. In addition, the +45T>G SNP was associated with reduced odds of the MUH phenotype.

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来源期刊
Lifestyle Genomics
Lifestyle Genomics Agricultural and Biological Sciences-Food Science
CiteScore
4.00
自引率
7.70%
发文量
11
审稿时长
28 weeks
期刊介绍: Lifestyle Genomics aims to provide a forum for highlighting new advances in the broad area of lifestyle-gene interactions and their influence on health and disease. The journal welcomes novel contributions that investigate how genetics may influence a person’s response to lifestyle factors, such as diet and nutrition, natural health products, physical activity, and sleep, amongst others. Additionally, contributions examining how lifestyle factors influence the expression/abundance of genes, proteins and metabolites in cell and animal models as well as in humans are also of interest. The journal will publish high-quality original research papers, brief research communications, reviews outlining timely advances in the field, and brief research methods pertaining to lifestyle genomics. It will also include a unique section under the heading “Market Place” presenting articles of companies active in the area of lifestyle genomics. Research articles will undergo rigorous scientific as well as statistical/bioinformatic review to ensure excellence.
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