植物乳杆菌、菊粉及其复合益生菌对健康大鼠下丘脑和血清的抗氧化和代谢作用

IF 2.3 Q3 NUTRITION & DIETETICS Nutrition and Metabolic Insights Pub Date : 2020-10-20 eCollection Date: 2020-01-01 DOI:10.1177/1178638820925092
Elaheh-Sadat Hosseinifard, Khadijeh Bavafa-Valenlia, Maryam Saghafi-Asl, Mohammad Morshedi
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摘要

如今,肠道微生物群与大脑之间的联系已备受关注。益生菌和益生元对糖尿病和肥胖症等多种疾病的有益代谢作用已有报道。然而,将肠道微生物群与健康状态下的大脑功能联系起来的研究却很少见。因此,我们假设服用植物乳杆菌(L plantarum)和菊粉可能会影响健康雄性大鼠的血清和下丘脑代谢参数以及氧化标记物。健康大鼠每日摄入植物乳杆菌(107 CFU/mL)和菊粉(占每日食物重量的5%)或它们的组合(合成益生菌)。然后测量血清和下丘脑中瘦素、胰岛素和氧化标记物的水平。服用合生元 8 周后,大鼠血清中的高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、极低密度脂蛋白胆固醇、低密度脂蛋白/高密度脂蛋白比率、甘油三酯和总胆固醇水平都发生了显著变化。摄入合生元还能显著降低下丘脑丙二醛水平,增加下丘脑超氧化物歧化酶(SOD)。植物乳杆菌也能显著提高下丘脑的 SOD 水平。此外,服用益生菌并不能显著提高下丘脑和血清中的胰岛素和瘦素水平。这些研究结果表明,合成益生菌可明显改善健康大鼠的氧化指标和血脂状况。因此,同时摄入植物乳杆菌和菊粉似乎能更有效地改善代谢和氧化指标。
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Antioxidative and Metabolic Effects of Lactobacillus plantarum, Inulin, and Their Synbiotic on the Hypothalamus and Serum of Healthy Rats.

Nowadays, much attention has been paid to the link between gut microbiota and brain. The beneficial metabolic effects of probiotics and prebiotics in several diseases such as diabetes and obesity have been reported. However, studies bridging the association of gut microbiome with brain function in healthy states are rare. Therefore, it was hypothesized that the administration of Lactobacillus plantarum (L plantarum) and inulin may affect serum and hypothalamic metabolic parameters as well as oxidative markers in healthy male rats. Daily L plantarum (107 CFU/mL) and inulin (5% of daily food weight) or their combination (synbiotic) was given to healthy rats. Then, serum and hypothalamic levels of leptin, insulin, and oxidative markers were measured. Administration of synbiotic for 8 weeks led to significant changes in serum levels of high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, very low-density lipoprotein cholesterol, low-density lipoprotein/high-density lipoprotein ratio, triglyceride, and total cholesterol. The intake of synbiotic also resulted in a significantly reduced hypothalamic level of malondialdehyde and increased hypothalamic superoxide dismutase (SOD). Also, L plantarum could significantly increase hypothalamic SOD level. Furthermore, synbiotic administration insignificantly increased the hypothalamic and serum levels of insulin and leptin. These findings suggest that the synbiotic could significantly improve oxidative markers and lipid profile in healthy rats. Therefore, simultaneous intake of L plantarum and inulin appears to be more effective in the amelioration of metabolic and oxidative parameters.

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来源期刊
Nutrition and Metabolic Insights
Nutrition and Metabolic Insights NUTRITION & DIETETICS-
CiteScore
3.30
自引率
0.00%
发文量
27
审稿时长
8 weeks
期刊介绍: Nutrition and Metabolic Insights is a peer-reviewed, open-access online journal focusing on all aspects of nutrition and metabolism. This encompasses nutrition, including the biochemistry of metabolism, exercise and associated physical processes and also includes clinical articles that relate to metabolism, such as obesity, lipidemias and diabetes. It includes research at the molecular, cellular and organismal levels. This journal welcomes new manuscripts for peer review on the following topics: Nutrition, including the biochemistry of metabolism, Exercise and associated physical processes, Clinical articles that relate to metabolism, such as obesity, lipidemias and diabetes, Research at the molecular, cellular and organismal levels, Other areas of interest include gene-nutrient interactions, the effects of hormones, models of metabolic function, macronutrient interactions, outcomes of changes in diet, and pathophysiology.
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