{"title":"耳念珠菌感染与生物膜形成:超越表面。","authors":"Mark V Horton, Jeniel E Nett","doi":"10.1007/s40588-020-00143-7","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose of review: </strong>Emergent fungal pathogen <i>C. auris</i> is spreading in hospitals throughout the world and mortality rates for patients with invasive disease approach 60%. This species exhibits a heightened capacity to colonize skin, persist on hospital surfaces, rapidly disseminate in healthcare settings, and resist antifungal therapy.</p><p><strong>Recent findings: </strong>Current investigations show that <i>C. auris</i> produces biofilms, surface-adherent communities that resist antifungals and withstand desiccation. These biofilms form when <i>C. auris</i> is growing on skin or in conditions expected in the hospital environment and on implanted medical devices.</p><p><strong>Summary: </strong>Here we will highlight the topic of biofilm formation by <i>C. auris</i>. We illustrate how this process influences resistance to antimicrobials and promotes nosocomial transmission.</p>","PeriodicalId":45506,"journal":{"name":"Current Clinical Microbiology Reports","volume":"7 3","pages":"51-56"},"PeriodicalIF":3.1000,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40588-020-00143-7","citationCount":"50","resultStr":"{\"title\":\"<i>Candida auris</i> infection and biofilm formation: going beyond the surface.\",\"authors\":\"Mark V Horton, Jeniel E Nett\",\"doi\":\"10.1007/s40588-020-00143-7\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose of review: </strong>Emergent fungal pathogen <i>C. auris</i> is spreading in hospitals throughout the world and mortality rates for patients with invasive disease approach 60%. This species exhibits a heightened capacity to colonize skin, persist on hospital surfaces, rapidly disseminate in healthcare settings, and resist antifungal therapy.</p><p><strong>Recent findings: </strong>Current investigations show that <i>C. auris</i> produces biofilms, surface-adherent communities that resist antifungals and withstand desiccation. These biofilms form when <i>C. auris</i> is growing on skin or in conditions expected in the hospital environment and on implanted medical devices.</p><p><strong>Summary: </strong>Here we will highlight the topic of biofilm formation by <i>C. auris</i>. We illustrate how this process influences resistance to antimicrobials and promotes nosocomial transmission.</p>\",\"PeriodicalId\":45506,\"journal\":{\"name\":\"Current Clinical Microbiology Reports\",\"volume\":\"7 3\",\"pages\":\"51-56\"},\"PeriodicalIF\":3.1000,\"publicationDate\":\"2020-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1007/s40588-020-00143-7\",\"citationCount\":\"50\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current Clinical Microbiology Reports\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1007/s40588-020-00143-7\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2020/7/17 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"MICROBIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Clinical Microbiology Reports","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1007/s40588-020-00143-7","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2020/7/17 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"MICROBIOLOGY","Score":null,"Total":0}
Candida auris infection and biofilm formation: going beyond the surface.
Purpose of review: Emergent fungal pathogen C. auris is spreading in hospitals throughout the world and mortality rates for patients with invasive disease approach 60%. This species exhibits a heightened capacity to colonize skin, persist on hospital surfaces, rapidly disseminate in healthcare settings, and resist antifungal therapy.
Recent findings: Current investigations show that C. auris produces biofilms, surface-adherent communities that resist antifungals and withstand desiccation. These biofilms form when C. auris is growing on skin or in conditions expected in the hospital environment and on implanted medical devices.
Summary: Here we will highlight the topic of biofilm formation by C. auris. We illustrate how this process influences resistance to antimicrobials and promotes nosocomial transmission.
期刊介绍：
Current Clinical Microbiology Reports commissions expert reviews from leading scientists at the forefront of research in microbiology. The journal covers this broad field by dividing it into four key main areas of study: virology, bacteriology, parasitology, and mycology. Within each of the four sections, experts from around the world address important aspects of clinical microbiology such as immunology, diagnostics, therapeutics, antibiotics and antibiotic resistance, and vaccines. Some of the world’s foremost authorities in the field of microbiology serve as section editors and editorial board members. Section editors select topics for which leading researchers are invited to contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, which are highlighted in annotated reference lists. These timely reviews of the literature examine the latest scientific discoveries and controversies as they emerge and are indispensable to both researchers and clinicians. The editorial board, composed of more than 20 internationally diverse members, reviews the annual table of contents, ensures that topics address all aspects of emerging research, and where applicable suggests topics of critical importance to various countries/regions.
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