巨细胞病毒感染:生物治疗的临床挑战?Secukinumab治疗持续免疫球蛋白M抗巨细胞病毒阳性无症状患者1例

IF 5.2 Q1 DERMATOLOGY Psoriasis (Auckland, N.Z.) Pub Date : 2020-11-27 eCollection Date: 2020-01-01 DOI:10.2147/PTT.S284701
Alessio Gambardella, Gaetano Licata, Giulia Calabrese, Alina De Rosa, Francesca Pagliuca, Roberto Alfano, Giuseppe Argenziano
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引用次数: 2

摘要

使用生物疗法是目前治疗免疫介导性炎症性疾病(IMID)的常见做法。目前,还没有关于巨细胞病毒(CMV)感染或在生物制剂治疗期间再激活的管理指南。此外,对于长时间持续免疫球蛋白(Ig)M抗巨细胞病毒阳性且必须接受生物药物治疗的无症状患者的管理,缺乏指导。我们报告的情况下,病人在这种情况下,谁与生物药物治疗牛皮癣是指。使用secukinumab获得了良好的临床反应,并在6个月的随访中保持。未发生感染性疾病或巨细胞病毒感染再激活。我们对此类病例的处理提出一些可能的指导方针。
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CMV Infection: A Clinical Challenge in Biological Therapy? The Case of Asymptomatic Patients with Persistent Positive Immunoglobulin M Anti-CMV Treated with Secukinumab.

The use of biological therapy is now common practice in the treatment of immune-mediated inflammatory diseases (IMID). Currently, there are no guidelines related to the management of cytomegalovirus (CMV) infections or reactivation during therapy with biological agents. Furthermore, there is a lack of guidance on the management of asymptomatic patients with persistent positive immunoglobulin (Ig)M anti-CMV after an extended period and who have to undergo therapy with biological agents. We report the case of a patient in this situation for whom treatment with biological drugs for psoriasis was indicated. A good clinical response was obtained with secukinumab and maintained during 6 months of follow-up. No infectious disease or reactivation of CMV infection occurred. We suggest some possible guidelines for the management of such cases.

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