韩国肥胖人群多基因风险评分与热量摄入的相互作用分析。

IF 2 4区 医学 Q3 GENETICS & HEREDITY Lifestyle Genomics Pub Date : 2021-01-01 Epub Date: 2020-12-10 DOI:10.1159/000511333
Won-Jun Lee, Ji Eun Lim, Hae Un Jung, Ji-One Kang, Taesung Park, Sungho Won, Sang Youl Rhee, Mi Kyung Kim, Yeon-Jung Kim, Bermseok Oh
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引用次数: 4

摘要

导读:肥胖是由于摄入和消耗卡路里的不平衡,导致与生活方式有关的疾病。尽管全基因组关联研究(GWAS)已经揭示了许多与肥胖相关的遗传因素,但这些因素与卡路里摄入的相互作用仍然未知。本研究旨在探讨卡路里摄入量与BMI多基因风险评分(PRS)之间的相互作用。方法:三个队列,即来自韩国协会资源(KARE;n = 8,736)、心血管疾病关联研究(CAVAS;n = 9,334)和健康体检者(HEXA;N = 28,445),用于本研究。从以前的GWAS中选择bmi相关基因位点。采用两种评分,即PRS和association (a)PRS;前者来自5个GWAS数据集的193个单核苷酸多态性(snp),后者来自3个韩国队列的62个snp(可能相关)(荟萃分析,p < 0.01)。结果:在所有3个队列中,PRS和aPRS与BMI显著相关,但与总热量摄入没有显著的相互作用。肥胖也得到了类似的结果。PRS和aPRS与肥胖显著相关,但与总热量摄入没有显著的相互作用。我们进一步分析了与蛋白质、脂肪和碳水化合物摄入的相互作用。结果与总热量摄入的结果相似,PRS和aPRS被发现与BMI或肥胖的三种营养成分中的任何一种的相互作用无关。讨论:在3个独立的韩国队列(总n = 35,094)中调查了BMI PRS与卡路里摄入的相互作用,没有发现肥胖的PRS与卡路里摄入之间的相互作用。
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Analysis of the Interaction between Polygenic Risk Score and Calorie Intake in Obesity in the Korean Population.

Introduction: Obesity results from an imbalance in the intake and expenditure of calories that leads to lifestyle-related diseases. Although genome-wide association studies (GWAS) have revealed many obesity-related genetic factors, the interactions of these factors and calorie intake remain unknown. This study aimed to investigate interactions between calorie intake and the polygenic risk score (PRS) of BMI.

Methods: Three cohorts, i.e., from the Korea Association REsource (KARE; n = 8,736), CArdioVAscular Disease Association Study (CAVAS; n = 9,334), and Health EXAminee (HEXA; n = 28,445), were used for this study. BMI-related genetic loci were selected from previous GWAS. Two scores, PRS, and association (a)PRS, were used; the former was determined from 193 single-nucleotide polymorphisms (SNPs) from 5 GWAS datasets, and the latter from 62 SNPs (potentially associated) from 3 Korean cohorts (meta-analysis, p < 0.01).

Results: PRS and aPRS were significantly associated with BMI in all 3 cohorts but did not exhibit a significant interaction with total calorie intake. Similar results were obtained for obesity. PRS and aPRS were significantly associated with obesity but did not show a significant interaction with total calorie intake. We further analyzed the interaction with protein, fat, and carbohydrate intake. The results were similar to those for total calorie intake, with PRS and aPRS found to not be associated with the interaction of any of the 3 nutrition components for either BMI or obesity.

Discussion: The interaction of BMI PRS with calorie intake was investigated in 3 independent Korean cohorts (total n = 35,094) and no interactions were found between PRS and calorie intake for obesity.

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来源期刊
Lifestyle Genomics
Lifestyle Genomics Agricultural and Biological Sciences-Food Science
CiteScore
4.00
自引率
7.70%
发文量
11
审稿时长
28 weeks
期刊介绍: Lifestyle Genomics aims to provide a forum for highlighting new advances in the broad area of lifestyle-gene interactions and their influence on health and disease. The journal welcomes novel contributions that investigate how genetics may influence a person’s response to lifestyle factors, such as diet and nutrition, natural health products, physical activity, and sleep, amongst others. Additionally, contributions examining how lifestyle factors influence the expression/abundance of genes, proteins and metabolites in cell and animal models as well as in humans are also of interest. The journal will publish high-quality original research papers, brief research communications, reviews outlining timely advances in the field, and brief research methods pertaining to lifestyle genomics. It will also include a unique section under the heading “Market Place” presenting articles of companies active in the area of lifestyle genomics. Research articles will undergo rigorous scientific as well as statistical/bioinformatic review to ensure excellence.
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