重组三价HPV疫苗(16/18/58)诱导的恒河猴非疫苗型交叉中和抗体滴度

Yan Wang , Yuying Liu , Shutian Liang , Fei Yin , Haijiang Zhang , Yongjiang Liu
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引用次数: 0

摘要

人乳头瘤病毒(HPV)不仅会导致大多数宫颈癌,还会导致阴道、外阴、阴茎、肛门、直肠和口咽部的癌症。全球每年有20万女性死于宫颈癌,其中中国约占10%。人乳头瘤病毒疫苗可有效预防人乳头瘤病毒感染,从而在世界范围内预防与人乳头瘤病毒有关的癌症。对2v Cervarix™和4v Gardasil®的临床试验研究表明,接种这两种疫苗中的任何一种都能提供一定程度的保护,防止与疫苗中所含类型密切相关的其他HPV类型。在这里,我们对针对HPV16、18和58的3v HPV疫苗在恒河猴中诱导交叉中和抗体的能力进行了初步评估,该疫苗是专门为中国女性设计的。我们发现该疫苗在恒河猴体内诱导抗非疫苗型HPV抗体的能力不低于Gardasil®。这些结果从免疫原性的角度提供了证据,证明KLWS 3v HPV疫苗是目前市场上进口的2v和4v HPV疫苗的有力竞争对手。
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Cross-neutralizing antibody titres against non-vaccine types induced by a recombinant trivalent HPV vaccine (16/18/58) in rhesus macaques

Human papillomavirus (HPV) causes not only most cervical cancers but also cancers of the vagina, vulva, penis, anus, rectum, and oropharynx. Every year, 200,000 women die of cervical cancer in the world, and China accounts for about 10%. HPV vaccines are effective in preventing HPV infections thus HPV-related cancers worldwide. Studies on the clinical trials of the 2v Cervarix™ and the 4v Gardasil® have suggested that immunization with either of these vaccines provided some level of protection against other HPV types that are closely related to the types contained in the vaccines. Here we conducted a preliminary evaluation on the ability to induce cross-neutralizing antibodies in rhesus monkeys by a 3v HPV vaccine that targets HPV16, 18, and 58 and it is specifically designed for Chinese women. We found that this vaccine is no less than Gardasil® in terms of the ability to induce NAbs against non-vaccine types of HPV in rhesus macaques. These results provided evidence from the immunogenicity point of view that the KLWS 3v HPV vaccine is a strong competitor to the imported 2v and 4v HPV vaccines currently available on the market.

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来源期刊
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0.00%
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审稿时长
14 weeks
期刊介绍: The official Journal of the International Papillomavirus Society Papillomavirus Research (PVR), the Journal of HPV and other Small DNA Tumor Viruses publishes innovative papers related to all aspects of papillomaviruses and other small DNA tumor viruses. The official journal of the International Papillomavirus Society, PVR is an open access publication that aims to bring together virologists, immunologists, epidemiologists and clinicians working in the booming field of HPV and animal papillomaviruses, polyomaviruses and other small DNA tumor viruses and their associated diseases, in order to foster and facilitate interdisciplinary communication. The journal welcomes original research articles, reviews, short communications, opinion articles and regional update reports on papillomaviruses and other tumor viruses in the following sections: a. Biology of papillomaviruses and related viruses from life cycle to cancer b. Epidemiology etiology and natural history studies c. Natural and induced immunity including vaccine research d. Intervention studies and strategies including i. Clinical studies and trials ii. HPV treatments iii. HPV vaccination programs iv. Diagnostics and screening e. Infection and disease prevention, modeling studies f. Guidelines and public health recommendations g. HPV Studies in special populations Regional and local studies on these viruses.
期刊最新文献
Prevalence, incidence, and natural history of HPV infection in adult women ages 24 to 45 participating in a vaccine trial Multiple HPV infections among men who have sex with men engaged in anal cancer screening in Abuja, Nigeria Long-term immunogenicity, effectiveness, and safety of nine-valent human papillomavirus vaccine in girls and boys 9 to 15 years of age: Interim analysis after 8 years of follow-up Associations between risk-perception, self-efficacy and vaccine response-efficacy and parent/guardian decision-making regarding adolescent HPV vaccination CINtec PLUS and cobas HPV testing for triaging Canadian women referred to colposcopy with a history of low-grade squamous intraepithelial lesion: Baseline findings
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