{"title":"慢性牙周炎与牙周影响支气管扩张患者炎症反应基因的差异表达。","authors":"Abhaya Gupta, Neetu Singh, Anil Kumar, Umesh Pratap Verma, Ajay Kumar Verma, Hari Shyam, Nand Lal, Surya Kant, Ankur Kumari","doi":"10.22099/mbrc.2020.37397.1508","DOIUrl":null,"url":null,"abstract":"<p><p>The study aimed to investigate differential expression of targeted inflammatory-immune responsive genes <i>[LTA, LTB, TNFSF4, TNFSF11/RANKL, TNFSF13, TNFSF13B, TNFRSF11B/ Osteoprotegerin; OPG</i> and <i>GFPT1/GFA</i> ] in gingival tissues of bronchiectasis patients having chronic periodontitis in North central Indian population. Gingival tissues were collected from 30 systemically healthy chronic periodontitis patients (CP), 30 bronchiectasis patients with chronic periodontitis (B+CP), 3 systemically healthy with healthy gingiva (healthy control; HC) and 3 bronchiectasis with healthy gingiva (bronchiectasis control; BC). Statistical analysis revealed 7 genes to be significantly upregulated on comparing CP with B+CP i.e <i>LTA</i> (P<0.0001) in B+CP while <i>LTB</i> (P<0.0001), <i>TNFSF4</i> (P=0.0003), <i>TNFSF11</i> (P<0.0001), <i>TNFSF13</i> (P=0.0003), <i>TNFSF13B</i> (P<0.0001) and <i>TNFRSF11B</i> (P=0.0004) in CP group. <i>LTA (Lymphotoxin A)</i> gene could be a potential genetic marker in bronchiectasis patients with chronic periodontitis.</p>","PeriodicalId":19025,"journal":{"name":"Molecular Biology Research Communications","volume":null,"pages":null},"PeriodicalIF":1.5000,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7731971/pdf/","citationCount":"1","resultStr":"{\"title\":\"Differential expression of inflammatory responsive genes between chronic periodontitis and periodontally affected bronchiectasis patients.\",\"authors\":\"Abhaya Gupta, Neetu Singh, Anil Kumar, Umesh Pratap Verma, Ajay Kumar Verma, Hari Shyam, Nand Lal, Surya Kant, Ankur Kumari\",\"doi\":\"10.22099/mbrc.2020.37397.1508\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The study aimed to investigate differential expression of targeted inflammatory-immune responsive genes <i>[LTA, LTB, TNFSF4, TNFSF11/RANKL, TNFSF13, TNFSF13B, TNFRSF11B/ Osteoprotegerin; OPG</i> and <i>GFPT1/GFA</i> ] in gingival tissues of bronchiectasis patients having chronic periodontitis in North central Indian population. Gingival tissues were collected from 30 systemically healthy chronic periodontitis patients (CP), 30 bronchiectasis patients with chronic periodontitis (B+CP), 3 systemically healthy with healthy gingiva (healthy control; HC) and 3 bronchiectasis with healthy gingiva (bronchiectasis control; BC). Statistical analysis revealed 7 genes to be significantly upregulated on comparing CP with B+CP i.e <i>LTA</i> (P<0.0001) in B+CP while <i>LTB</i> (P<0.0001), <i>TNFSF4</i> (P=0.0003), <i>TNFSF11</i> (P<0.0001), <i>TNFSF13</i> (P=0.0003), <i>TNFSF13B</i> (P<0.0001) and <i>TNFRSF11B</i> (P=0.0004) in CP group. <i>LTA (Lymphotoxin A)</i> gene could be a potential genetic marker in bronchiectasis patients with chronic periodontitis.</p>\",\"PeriodicalId\":19025,\"journal\":{\"name\":\"Molecular Biology Research Communications\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.5000,\"publicationDate\":\"2020-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7731971/pdf/\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Molecular Biology Research Communications\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.22099/mbrc.2020.37397.1508\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"BIOCHEMISTRY & MOLECULAR BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Molecular Biology Research Communications","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.22099/mbrc.2020.37397.1508","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
Differential expression of inflammatory responsive genes between chronic periodontitis and periodontally affected bronchiectasis patients.
The study aimed to investigate differential expression of targeted inflammatory-immune responsive genes [LTA, LTB, TNFSF4, TNFSF11/RANKL, TNFSF13, TNFSF13B, TNFRSF11B/ Osteoprotegerin; OPG and GFPT1/GFA ] in gingival tissues of bronchiectasis patients having chronic periodontitis in North central Indian population. Gingival tissues were collected from 30 systemically healthy chronic periodontitis patients (CP), 30 bronchiectasis patients with chronic periodontitis (B+CP), 3 systemically healthy with healthy gingiva (healthy control; HC) and 3 bronchiectasis with healthy gingiva (bronchiectasis control; BC). Statistical analysis revealed 7 genes to be significantly upregulated on comparing CP with B+CP i.e LTA (P<0.0001) in B+CP while LTB (P<0.0001), TNFSF4 (P=0.0003), TNFSF11 (P<0.0001), TNFSF13 (P=0.0003), TNFSF13B (P<0.0001) and TNFRSF11B (P=0.0004) in CP group. LTA (Lymphotoxin A) gene could be a potential genetic marker in bronchiectasis patients with chronic periodontitis.
期刊介绍：
“Molecular Biology Research Communications” (MBRC) is an international journal of Molecular Biology. It is published quarterly by Shiraz University (Iran). The MBRC is a fully peer-reviewed journal. The journal welcomes submission of Original articles, Short communications, Invited review articles, and Letters to the Editor which meets the general criteria of significance and scientific excellence in all fields of “Molecular Biology”.
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