交感肠连接驱动Roux-en-Y胃旁路术的代谢益处。

IF 4.1 Q2 CELL BIOLOGY Cell Stress Pub Date : 2020-11-24 DOI:10.15698/cst2020.12.236

Mohammed K Hankir

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引用次数: 2

摘要

许多人认为手术是治疗严重肥胖的首选方法;然而，在身体上改变胃肠道是如何对体重和整体代谢健康产生如此显著的影响的，人们知之甚少。在最近一期的《细胞报告》(Cell Reports)中，Ye等人(2020)比较了Roux-en-Y胃旁路手术(RYGB)和袖胃切除术(SG)的小鼠模型，这是目前临床上最常用的两种减肥手术，结果表明，前者的重新配置手术通过内脏神经介导的肠系膜白色脂肪褐化选择性地增加静息代谢率。更重要的是，他们证明了RYGB的这种作用是维持负能量平衡和改善血糖控制所必需的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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A sympathetic gut connection drives the metabolic benefits of Roux-en-Y gastric bypass.

Surgery is regarded by many as the go-to treatment option for severe obesity; yet how physically altering the gastrointestinal tract produces such striking results on body weight and overall metabolic health is poorly understood. In a recent issue of Cell Reports Ye et al. (2020) compare mouse models of Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG), the two most commonly performed weight loss surgeries in the clinic today, to show that the former reconfiguring procedure selectively increases resting metabolic rate through splanchnic nerve-mediated browning of mesenteric white fat. More significantly, they demonstrate that this effect for RYGB is required for the maintained negative energy balance and improved glycemic control that it confers.

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来源期刊

Cell Stress Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (miscellaneous)

CiteScore

13.50

自引率

0.00%

发文量

审稿时长

15 weeks

期刊介绍： Cell Stress is an open-access, peer-reviewed journal that is dedicated to publishing highly relevant research in the field of cellular pathology. The journal focuses on advancing our understanding of the molecular, mechanistic, phenotypic, and other critical aspects that underpin cellular dysfunction and disease. It specifically aims to foster cell biology research that is applicable to a range of significant human diseases, including neurodegenerative disorders, myopathies, mitochondriopathies, infectious diseases, cancer, and pathological aging. The scope of Cell Stress is broad, welcoming submissions that represent a spectrum of research from fundamental to translational and clinical studies. The journal is a valuable resource for scientists, educators, and policymakers worldwide, as well as for any individual with an interest in cellular pathology. It serves as a platform for the dissemination of research findings that are instrumental in the investigation, classification, diagnosis, and therapeutic management of major diseases. By being open-access, Cell Stress ensures that its content is freely available to a global audience, thereby promoting international scientific collaboration and accelerating the exchange of knowledge within the research community.