促进或抑制胶质瘤的进展,这是IL-33的问题。

IF 4.1 Q2 CELL BIOLOGY Cell Stress Pub Date : 2020-12-03 DOI:10.15698/cst2021.01.240
Stephen M Robbins, Donna L Senger
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引用次数: 0

摘要

IL-33是IL-1细胞因子家族的一员,已被证明在体内发挥双重作用。首先,IL-33与其他IL-1家族成员相似,是一种分泌性细胞因子,与细胞表面受体ST2结合,诱导多种细胞信号通路。其次,IL-33进入细胞核,与染色质结合,指导一系列生长因子和细胞因子的转录控制。与其复杂的细胞调控一致,IL-33通过作用于广泛的先天和适应性免疫细胞介导一系列生物学功能。最近,我们发现IL-33在大量人类胶质瘤患者标本中表达,其在肿瘤内的表达与Iba+细胞(包括常驻小胶质细胞和募集的单核细胞和巨噬细胞)的增加相关。引人注目的是,胶质瘤源性IL-33的表达与荷瘤动物总存活率的急剧下降相关,因此支持其作为胶质瘤形成的一个影响因素的作用。然而,值得注意的是,当IL-33的核定位功能被破坏时,肿瘤微环境被编程为抗致瘤性,并导致延长总生存期,这表明,如果教育得当,这可能代表一种新的治疗胶质瘤的策略(De Boeck等人(2020),Nat common, doi: 10.1038/s41467-020-18569-4)。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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To promote or inhibit glioma progression, that is the question for IL-33.

IL-33, a member of the IL-1 cytokine family has been shown to play a dual role within the body. First IL-33, similar to other IL-1 family members, is a secreted cytokine that binds to the cell surface receptor ST2 to induce a number of cell signaling pathways. Second, IL-33 enters the nucleus where it binds chromatin and directs transcriptional control of an array of growth factors and cytokines. Consistent with its complex cellular regulation, IL-33 mediates an array of biological functions by acting on a wide range of innate and adaptive immune cells. Recently, we found that IL-33 is expressed in a large number of human glioma patient specimens where its expression within the tumor correlates with the increased presence of Iba+ cells that include both resident microglia and recruited monocyte and macrophages. Strikingly, glioma derived expression of IL-33 correlates with a dramatic decrease in overall survival of tumor-bearing animals and thus supports its role as an influential factor in gliomagenesis. Notably however, when the nuclear localization function of IL-33 is crippled, the tumor microenvironment is programmed to be anti-tumorigenic and results in prolonged overall survival suggesting that when educated appropriately this could represent a novel therapeutic strategy for glioma (De Boeck et al. (2020), Nat Commun, doi: 10.1038/s41467-020-18569-4).

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来源期刊
Cell Stress
Cell Stress Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (miscellaneous)
CiteScore
13.50
自引率
0.00%
发文量
21
审稿时长
15 weeks
期刊介绍: Cell Stress is an open-access, peer-reviewed journal that is dedicated to publishing highly relevant research in the field of cellular pathology. The journal focuses on advancing our understanding of the molecular, mechanistic, phenotypic, and other critical aspects that underpin cellular dysfunction and disease. It specifically aims to foster cell biology research that is applicable to a range of significant human diseases, including neurodegenerative disorders, myopathies, mitochondriopathies, infectious diseases, cancer, and pathological aging. The scope of Cell Stress is broad, welcoming submissions that represent a spectrum of research from fundamental to translational and clinical studies. The journal is a valuable resource for scientists, educators, and policymakers worldwide, as well as for any individual with an interest in cellular pathology. It serves as a platform for the dissemination of research findings that are instrumental in the investigation, classification, diagnosis, and therapeutic management of major diseases. By being open-access, Cell Stress ensures that its content is freely available to a global audience, thereby promoting international scientific collaboration and accelerating the exchange of knowledge within the research community.
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