p62/SQSTM1液滴启动自噬体生物发生和氧化应激控制。

IF 2.6 Q3 ONCOLOGY Molecular and Cellular Oncology Pub Date : 2021-03-09 DOI:10.1080/23723556.2021.1890990

Eeva-Liisa Eskelinen, Shun Kageyama, Masaaki Komatsu

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引用次数: 6

摘要

选择性自噬有助于冷凝物的降解，如封存体1，也称为p62/ sqstm1体。我们发现内源性p62形成凝胶状结构，作为自噬体形成和核因子红细胞2相关因子2 (NRF2)激活的平台。此外，p62介导的NRF2激活不具有细胞毒性，但NRF2激活与体积和选择性自噬受损的结合会导致肝损伤。

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p62/SQSTM1 droplets initiate autophagosome biogenesis and oxidative stress control.

Selective autophagy contributes to the degradation of condensates, such as sequestosome 1-bodies, also called p62/SQSTM1-bodies. We showed that endogenous p62 forms gel-like structures, which serve as platforms for autophagosome formation and nuclear factor erythroid 2-related factor 2 (NRF2) activation. Further, p62-mediated NRF2 activation is not cytotoxic, but combination of NRF2 activation with impaired bulk and selective autophagy causes liver injury.

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来源期刊

Molecular and Cellular Oncology Biochemistry, Genetics and Molecular Biology-Cancer Research

CiteScore

3.20

自引率

0.00%

发文量

期刊介绍： For a long time, solid neoplasms have been viewed as relatively homogeneous entities composed for the most part of malignant cells. It is now clear that tumors are highly heterogeneous structures that evolve in the context of intimate interactions between cancer cells and endothelial, stromal as well as immune cells. During the past few years, experimental and clinical oncologists have witnessed several conceptual transitions of this type. Molecular and Cellular Oncology (MCO) emerges within this conceptual framework as a high-profile forum for the publication of fundamental, translational and clinical research on cancer. The scope of MCO is broad. Submissions dealing with all aspects of oncogenesis, tumor progression and response to therapy will be welcome, irrespective of whether they focus on solid or hematological neoplasms. MCO has gathered leading scientists with expertise in multiple areas of cancer research and other fields of investigation to constitute a large, interdisciplinary, Editorial Board that will ensure the quality of articles accepted for publication. MCO will publish Original Research Articles, Brief Reports, Reviews, Short Reviews, Commentaries, Author Views (auto-commentaries) and Meeting Reports dealing with all aspects of cancer research.