Covid-19 美国和欧洲根据法定任务采取的拉开社会距离干预措施及其与死亡率的观察相关性》(Covid-19 Social Distancing Interventions by Statutory Mandate and Their Observational Correlation to Mortality in the United States and Europe)。

IF 2.3 Q2 MEDICINE, GENERAL & INTERNAL Pragmatic and Observational Research Pub Date : 2021-04-27 eCollection Date: 2021-01-01 DOI:10.2147/POR.S298309
Sean Mccafferty, Sean Ashley
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摘要

目的:独立评估美国和欧洲法定社会疏远干预措施与 Covid-19 死亡率之间的相关性。该研究是评估法定社会疏导政策有效性的一种潜在方法:从美国卫生计量与评估研究所(IHME)的数据中选取了美国的 27 个州,并分别选取了 12 个欧洲国家,这些州和国家都明确规定了在全州或全国范围内采取拉开社会距离措施的日期。本研究考虑的强制性社会隔离措施包括学校关闭、禁止大规模集会、企业关闭、在家休息、严格的旅行限制和关闭非必要企业。州/国家 Covid-19 峰值死亡率 (PMR) 被定义为社会隔离措施生效期间的初始平均归一化最大值。授权天数定义为立法授权与 PMR 之间的总天数:美国和欧洲的正常化峰值死亡率与授权总天数在统计上没有显著的相关性(R-平方=0.053,p=0.246,R-平方=2.4E-06,p=0.996)。归一化死亡率与州/国家人口密度之间存在明显的相关性(R-平方=0.524,p=0.00002,R-平方=0.397,p=0.0281):分析表明,在解释平均效应时,Covid-19 死亡率并没有有效降低到其确定的初始峰值。与人口密度的强相关性表明,人类互动频率确实会影响死亡率峰值。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Covid-19 Social Distancing Interventions by Statutory Mandate and Their Observational Correlation to Mortality in the United States and Europe.

Purpose: Evaluate the correlation between statutory social distancing interventions and Covid-19 mortality independently in both the United States and Europe. The study is presented as a potential methodology to evaluate the effectiveness of statutory social distancing policy.

Patients and methods: Twenty-seven states in the United States and, separately, 12 European countries were selected which had clearly defined and dated establishment of statewide or national mandates for social distancing measures from the Institute for Health Metrics and Evaluation (IHME) data. Mandated social distancing measures considered in this study include: School closures, Prohibition on mass gatherings, business closures, stay at home orders, severe travel restrictions, and closure of non-essential businesses. The state/country Covid-19 peak mortality rate (PMR) was defined as the initial averaged normalized maximum during which social distancing mandates were in effect. Mandate-days were defined as the total days legislative mandates were in place to the PMR.

Results: The normalized peak mortality rate in the US and in Europe did not demonstrate a statistically significant correlation to the total mandate days (R-squared=0.053, p=0.246, R-squared=2.4E-06, p=0.996). A significant correlation was found between normalized mortality rate and state/country population density (R-squared=0.524, p=0.00002,R-squared=0.397, p=0.0281).

Discussion: The analysis appears to suggest no mandate effective reduction in Covid-19 mortality rate to its defined initial peak when interpreting their mean-effect. A strong correlation to population density suggests human interaction frequency does affect the peak mortality rate.

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Pragmatic and Observational Research
Pragmatic and Observational Research MEDICINE, GENERAL & INTERNAL-
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期刊介绍: Pragmatic and Observational Research is an international, peer-reviewed, open-access journal that publishes data from studies designed to closely reflect medical interventions in real-world clinical practice, providing insights beyond classical randomized controlled trials (RCTs). While RCTs maximize internal validity for cause-and-effect relationships, they often represent only specific patient groups. This journal aims to complement such studies by providing data that better mirrors real-world patients and the usage of medicines, thus informing guidelines and enhancing the applicability of research findings across diverse patient populations encountered in everyday clinical practice.
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