扁平地衣氧化应激新标志物及丙型肝炎病毒感染的影响-一项初步研究。

IF 1.6 Q2 MEDICINE, GENERAL & INTERNAL Romanian Journal of Internal Medicine Pub Date : 2021-11-20 Print Date: 2021-12-01 DOI:10.2478/rjim-2021-0017
Madalina Irina Mitran, Mircea Tampa, Ilinca Nicolae, Cristina Iulia Mitran, Clara Matei, Simona Roxana Georgescu, Mircea Ioan Popa
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引用次数: 1

摘要

介绍。扁平苔藓(LP)是一种病因不明的粘膜皮肤t细胞介导的疾病。越来越多的证据表明氧化应激在LP的发病机制中起着重要的作用。因此,我们研究了LP中的氧化应激标志物以及丙型肝炎病毒(HCV)感染(一种常见的相关疾病)对LP患者氧化应激的影响。方法。我们测定了4-羟基壬烯醛(4- hne)和对称二甲基精氨酸(SDMA)的血清水平,作为氧化应激的标志物,以及总抗氧化能力(TAC),作为抗氧化防御的标志物,在4组中:a - HCV阳性LP患者(n=12), B - HCV阳性无LP患者(n=12), C - HCV阴性LP患者(n=31)和D -对照组(n=26)。结果。在LP患者中,我们已确定增加的脂质过氧化水平(4-HNE - A组8.41±1.11μg / mL, B组- 7.97±2.17μg / mL, C组- 7.81±1.96μg / mL和组D - 6.15±1.17μg / mL)和精氨酸甲基化的改变(SDMA - A组1.10±0.24μmol / L, B组- 1.03±0.16μmol / L, C组- 0.84±0.19μmol / L和组D - 0.50±0.06μmol / L)与降低抗氧化防御(TAC - A组234.50±49.96μmol / L B组- 255.83±41.41μmol / L,C组- 269.83±43.33 μmol/L, D组- 316.46±29.33 μmol/L),与HCV感染相关而增强。结论。在LP患者中,氧化剂和抗氧化剂之间存在不平衡,这种不平衡因HCV感染而加剧。SDMA可以被认为是这些患者氧化应激的一种新的生物标志物。据我们所知,这是第一个调查HCV感染对LP患者氧化应激影响的研究。
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New markers of oxidative stress in lichen planus and the influence of hepatitis C virus infection - a pilot study.

Introduction. Lichen planus (LP) is a mucocutaneous T-cell mediated disorder of unknown etiology. There is growing evidence that oxidative stress is an important player in the pathogenesis of LP. Therefore, we have investigated oxidative stress markers in LP and the influence of hepatitis C virus (HCV) infection, a frequently associated condition, on oxidative stress in LP patients. Method. We have determined the serum levels of 4- hydroxynonenal (4-HNE) and symmetric dimethylarginine (SDMA), as markers of oxidative stress, and total antioxidant capacity (TAC), as a marker of the antioxidant defence, in 4 groups: group A - HCV positive patients with LP (n=12), group B - HCV positive patients without LP (n=12), group C - HCV negative patients with LP (n=31) and group D - control group (n=26). Results. In LP patients, we have identified an increased level of lipid peroxidation (4-HNE - group A - 8.41±1.11 μg/mL, group B - 7.97±2.17 μg/mL, group C - 7.81±1.96 μg/mL and group D - 6.15±1.17 μg/mL) and alterations in arginine methylation (SDMA - group A - 1.10±0.24 μmol/L, group B - 1.03±0.16 μmol/L, group C - 0.84±0.19 μmol/L and group D - 0.50±0.06 μmol/L) associated with a diminished antioxidant defence (TAC - group A - 234.50±49.96, μmol/L group B - 255.83±41.41 μmol/L, group C - 269.83±43.33 μmol/L and group D - 316.46 ±29.33 μmol/L), processes augmented by the association with HCV infection. Conclusion. There is an imbalance between oxidants and antioxidants in patients with LP, an imbalance that is augmented by the presence of HCV infection. SDMA could be regarded as a novel biomarker of oxidative stress among these patients. To the best of our knowledge this is the first study to investigate the influence of HCV infection on oxidative stress in LP patients.

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来源期刊
Romanian Journal of Internal Medicine
Romanian Journal of Internal Medicine MEDICINE, GENERAL & INTERNAL-
CiteScore
3.20
自引率
5.30%
发文量
35
审稿时长
15 weeks
期刊介绍: Romanian Journal of Physics is a journal publishing physics contributions on the following themes: •Theoretical Physics & Applied Mathematics •Nuclear Physics •Solid State Physics & Materials Science •Statistical Physics & Quantum Mechanics •Optics •Spectroscopy •Plasma & Lasers •Nuclear & Elementary Particles Physics •Atomic and Molecular Physics •Astrophysics •Atmosphere and Earth Science •Environment Protection
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