青光眼和黄斑变性的大脑改变:当前文献证据分析及其对治疗前景的影响。

IF 3.1 Q1 OPHTHALMOLOGY Eye and Brain Pub Date : 2021-06-17 eCollection Date: 2021-01-01 DOI:10.2147/EB.S307551
Raffaele Nuzzi, Alessio Vitale
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引用次数: 4

摘要

青光眼和黄斑变性是不可逆性失明的主要原因,严重影响生活质量,并具有很高的经济和社会影响。有希望的治疗方法旨在再生或绕过受损的解剖功能部件,目前正在开发中:这些方法产生了很大的期望,但要有效,需要一个视觉网络,尽管病理,保持其完整性到更高的大脑区域。鉴于此,关于青光眼和黄斑变性病理性损伤后中枢神经系统如何改变其连接的现有发现引起了人们的极大兴趣。本文旨在回顾有关在这些病理条件下影响中枢神经系统的形态和功能变化的科学文献,以分析的方式总结证据,讨论其可能的原因,并强调对当前治疗前景的潜在影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Cerebral Modifications in Glaucoma and Macular Degeneration: Analysis of Current Evidence in Literature and Their Implications on Therapeutic Perspectives.

Glaucoma and macular degeneration are leading causes of irreversible blindness, significantly compromising the quality of life and having a high economic and social impact. Promising therapeutic approaches aimed at regenerating or bypassing the damaged anatomical-functional components are currently under development: these approaches have generated great expectations, but to be effective require a visual network that, despite the pathology, maintains its integrity up to the higher brain areas. In the light of this, the existing findings concerning how the central nervous system modifies its connections following the pathological damage caused by glaucoma and macular degeneration acquire great interest. This review aims to examine the scientific literature concerning the morphological and functional changes affecting the central nervous system in these pathological conditions, summarizing the evidence in an analytical way, discussing their possible causes and highlighting the potential repercussions on the current therapeutic perspectives.

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来源期刊
Eye and Brain
Eye and Brain OPHTHALMOLOGY-
CiteScore
7.90
自引率
2.30%
发文量
12
审稿时长
16 weeks
期刊介绍: Eye and Brain is an international, peer-reviewed, open access journal focusing on basic research, clinical findings, and expert reviews in the field of visual science and neuro-ophthalmology. The journal’s unique focus is the link between two well-known visual centres, the eye and the brain, with an emphasis on the importance of such connections. All aspects of clinical and especially basic research on the visual system are addressed within the journal as well as significant future directions in vision research and therapeutic measures. This unique journal focuses on neurological aspects of vision – both physiological and pathological. The scope of the journal spans from the cornea to the associational visual cortex and all the visual centers in between. Topics range from basic biological mechanisms to therapeutic treatment, from simple organisms to humans, and utilizing techniques from molecular biology to behavior. The journal especially welcomes primary research articles or review papers that make the connection between the eye and the brain. Specific areas covered in the journal include: Physiology and pathophysiology of visual centers, Eye movement disorders and strabismus, Cellular, biochemical, and molecular features of the visual system, Structural and functional organization of the eye and of the visual cortex, Metabolic demands of the visual system, Diseases and disorders with neuro-ophthalmic manifestations, Clinical and experimental neuro-ophthalmology and visual system pathologies, Epidemiological studies.
期刊最新文献
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