{"title":"婴儿alk -1阴性间变性大细胞淋巴瘤表现为硬脑膜肿块。","authors":"Nishtha Ahuja, Rahul Sharma, Kirti Gupta, Karalanglin Tiewsoh, Pravin Salunke, Chandrashekhar Gendle, Richa Jain, Amita Trehan","doi":"10.5414/NP301395","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Anaplastic large-cell lymphoma (ALCL) rarely occurs in the central nervous system in the pediatric population.</p><p><strong>Case presentation: </strong>We describe a diagnostically challenging case of an 11-month-old infant presenting with cranial nerve palsies and peripheral eosinophilia. Imaging demonstrated meningeal thickening with enhancement and dura-based deposits, the biopsy of which revealed features of ALK-1 negative ALCL on histologic and immunophenotypic analysis. A thorough investigation excluded the possibility of any extra-cranial origin. Hence, a diagnosis of \"primary\" ALCL was rendered.</p><p><strong>Conclusion: </strong>ALCL arising in the dura in an infant has not been described earlier, to the best of our knowledge.</p>","PeriodicalId":55251,"journal":{"name":"Clinical Neuropathology","volume":null,"pages":null},"PeriodicalIF":0.8000,"publicationDate":"2021-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"ALK-1-negative anaplastic large-cell lymphoma presenting as a dura-based mass in an infant.\",\"authors\":\"Nishtha Ahuja, Rahul Sharma, Kirti Gupta, Karalanglin Tiewsoh, Pravin Salunke, Chandrashekhar Gendle, Richa Jain, Amita Trehan\",\"doi\":\"10.5414/NP301395\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>Anaplastic large-cell lymphoma (ALCL) rarely occurs in the central nervous system in the pediatric population.</p><p><strong>Case presentation: </strong>We describe a diagnostically challenging case of an 11-month-old infant presenting with cranial nerve palsies and peripheral eosinophilia. Imaging demonstrated meningeal thickening with enhancement and dura-based deposits, the biopsy of which revealed features of ALK-1 negative ALCL on histologic and immunophenotypic analysis. A thorough investigation excluded the possibility of any extra-cranial origin. Hence, a diagnosis of \\\"primary\\\" ALCL was rendered.</p><p><strong>Conclusion: </strong>ALCL arising in the dura in an infant has not been described earlier, to the best of our knowledge.</p>\",\"PeriodicalId\":55251,\"journal\":{\"name\":\"Clinical Neuropathology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.8000,\"publicationDate\":\"2021-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical Neuropathology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.5414/NP301395\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"CLINICAL NEUROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Neuropathology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.5414/NP301395","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
ALK-1-negative anaplastic large-cell lymphoma presenting as a dura-based mass in an infant.
Introduction: Anaplastic large-cell lymphoma (ALCL) rarely occurs in the central nervous system in the pediatric population.
Case presentation: We describe a diagnostically challenging case of an 11-month-old infant presenting with cranial nerve palsies and peripheral eosinophilia. Imaging demonstrated meningeal thickening with enhancement and dura-based deposits, the biopsy of which revealed features of ALK-1 negative ALCL on histologic and immunophenotypic analysis. A thorough investigation excluded the possibility of any extra-cranial origin. Hence, a diagnosis of "primary" ALCL was rendered.
Conclusion: ALCL arising in the dura in an infant has not been described earlier, to the best of our knowledge.
期刊介绍：
Clinical Neuropathology appears bi-monthly and publishes reviews and editorials, original papers, short communications and reports on recent advances in the entire field of clinical neuropathology. Papers on experimental neuropathologic subjects are accepted if they bear a close relationship to human diseases. Correspondence (letters to the editors) and current information including book announcements will also be published.
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