VAP是什么:扩展的VAP蛋白家族与FFAT和FFAT相关基序相互作用的细胞器间接触。

Contact (Thousand Oaks (Ventura County, Calif.)) Pub Date : 2021-05-09 eCollection Date: 2021-01-01 DOI:10.1177/25152564211012246
Jacques Neefjes, Birol Cabukusta
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引用次数: 11

摘要

膜接触点是由能够将两个细胞器膜连接在一起的系链蛋白形成的。VAP蛋白是一类内质网(ER)系链蛋白,专门与其他蛋白质中的FFAT(酸性通道中的两种苯丙氨酸)肽基序相互作用。如果含有ffat基序的蛋白存在于其他细胞器上,VAP蛋白在这些细胞器和内质网之间形成接触位点。VAPA和VAPB是VAP家族的两个创始成员,它们在向内质网募集蛋白质和形成膜接触位点方面的作用得到了很好的认识,因为VAPA和VAPB在不同细胞内接触位点的许多相互作用伙伴已经被表征。最近,三个新的蛋白-MOSPD1, MOSPD2和mospd3 -被添加到VAP家族。虽然MOSPD2具有与VAPA和VAPB相似的基序偏好,但MOSPD1和MOSPD3更倾向于与含有FFNT(中性通道中的两种苯丙氨酸)基序的蛋白质相互作用。本文综述了近年来VAP蛋白结合基序的研究进展以及VAP蛋白参与的其他生物过程。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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What the VAP: The Expanded VAP Family of Proteins Interacting With FFAT and FFAT-Related Motifs for Interorganellar Contact.

Membrane contact sites are formed by tether proteins that have the ability to bring two organellar membranes together. VAP proteins are a family of endoplasmic reticulum (ER)-resident tether proteins specialized in interacting with FFAT (two phenylalanines in an acidic tract) peptide motifs in other proteins. If the FFAT-motif-containing proteins reside on other organelles, VAP proteins form contact sites between these organelles and the ER. The role of VAPA and VAPB, the two founding members of the VAP family in recruiting proteins to the ER and forming membrane contact sites is well appreciated as numerous interaction partners of VAPA and VAPB at different intracellular contact sites have been characterized. Recently, three new proteins -MOSPD1, MOSPD2 and MOSPD3-have been added to the VAP family. While MOSPD2 has a motif preference similar to VAPA and VAPB, MOSPD1 and MOSPD3 prefer to interact with proteins containing FFNT (two phenylalanines in a neutral tract) motifs. In this review, we discuss the recent advances in motif binding by VAP proteins along with the other biological processes VAP proteins are involved in.

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