Benoit Champigneulle, Ivan Hancco, Richard Renan, Stéphane Doutreleau, Emeric Stauffer, Aurélien Pichon, Julien V Brugniaux, Hélène Péré, Pierre Bouzat, David Veyer, Samuel Verges
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Aims of this study were to estimate severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) seropositivity as well as the risk factors associated in La Rinconada, the highest city in the world (5,100-5,300 m), a gold-mining town located in southeastern Peru where >50,000 dwellers live in precarious sanitary conditions. <b><i>Materials and Methods:</i></b> We performed a cross-sectional study during a 1-week period in October 2020, using point-of-care lateral flow serological assays allowing detection of antibodies directed against SARS-CoV-2 among voluntary dwellers in La Rinconada. Participants were also questioned about potential occupational and environmental risk factors of COVID-19 occurrence. <b><i>Results:</i></b> In a sample of 159 dwellers tested in La Rinconada, 48.4% [95% confidence interval, CI: 40.5-56.4] were seropositive for the SARS-CoV-2. Occurrence of at least one symptom compatible with the COVID-19 over the past 6 months remained the only significant factor associated with SARS-CoV-2 seropositivity (adjusted odds ratio: 3.27; [95% CI: 1.70-6.44]; <i>p</i> < 0.001). <b><i>Conclusions:</i></b> The high rate of SARS-CoV-2 seropositivity observed in this small sample of highlanders does not support a protective effect of high-altitude against the COVID-19 spread and demonstrates its large dissemination in vulnerable populations. Clinical Trial Registration number: NCT04604249.</p>","PeriodicalId":12975,"journal":{"name":"High altitude medicine & biology","volume":" ","pages":"218-222"},"PeriodicalIF":1.6000,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"High-Altitude Environment and COVID-19: SARS-CoV-2 Seropositivity in the Highest City in the World.\",\"authors\":\"Benoit Champigneulle, Ivan Hancco, Richard Renan, Stéphane Doutreleau, Emeric Stauffer, Aurélien Pichon, Julien V Brugniaux, Hélène Péré, Pierre Bouzat, David Veyer, Samuel Verges\",\"doi\":\"10.1089/ham.2021.0020\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Champigneulle, Benoit, Ivan Hancco, Richard Renan, Stéphane Doutreleau, Emeric Stauffer, Aurélien Pichon, Julien V. Brugniaux, Hélène Péré, Pierre Bouzat, David Veyer, and Samuel Verges. High-altitude environment and COVID-19: SARS-CoV-2 seropositivity in the highest city in the world. <i>High Alt Med Biol.</i> 22: 000-000, 2021. <b><i>Background:</i></b> A reduced coronavirus disease 2019 (COVID-19) diffusion has been suggested in high-altitude areas but remained questionable. Aims of this study were to estimate severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) seropositivity as well as the risk factors associated in La Rinconada, the highest city in the world (5,100-5,300 m), a gold-mining town located in southeastern Peru where >50,000 dwellers live in precarious sanitary conditions. <b><i>Materials and Methods:</i></b> We performed a cross-sectional study during a 1-week period in October 2020, using point-of-care lateral flow serological assays allowing detection of antibodies directed against SARS-CoV-2 among voluntary dwellers in La Rinconada. Participants were also questioned about potential occupational and environmental risk factors of COVID-19 occurrence. <b><i>Results:</i></b> In a sample of 159 dwellers tested in La Rinconada, 48.4% [95% confidence interval, CI: 40.5-56.4] were seropositive for the SARS-CoV-2. Occurrence of at least one symptom compatible with the COVID-19 over the past 6 months remained the only significant factor associated with SARS-CoV-2 seropositivity (adjusted odds ratio: 3.27; [95% CI: 1.70-6.44]; <i>p</i> < 0.001). <b><i>Conclusions:</i></b> The high rate of SARS-CoV-2 seropositivity observed in this small sample of highlanders does not support a protective effect of high-altitude against the COVID-19 spread and demonstrates its large dissemination in vulnerable populations. 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引用次数: 0
摘要
Champigneulle, Benoit, Ivan Hancco, Richard Renan, Stéphane Doutreleau, Emeric Stauffer, Aurélien Pichon, Julien V. Brugniaux, Hélène Péré, Pierre Bouzat, David Veyer, and Samuel Verges.高海拔环境与 COVID-19:世界海拔最高城市的 SARS-CoV-2 血清阳性反应。22: 000-000, 2021.背景:有人认为冠状病毒疾病2019(COVID-19)在高海拔地区的扩散会减弱,但仍有疑问。本研究的目的是估计拉林科纳达(La Rinconada)的严重急性呼吸系统综合征冠状病毒 2(SARS-CoV-2)血清阳性率以及相关风险因素。拉林科纳达是世界上海拔最高的城市(海拔 5100-5300 米),位于秘鲁东南部,是一个金矿小镇,超过 50,000 名居民生活在不稳定的卫生条件下。材料与方法我们在 2020 年 10 月进行了一项为期一周的横断面研究,采用的是护理点侧流血清学检测法,可以在拉林科纳达的自愿居民中检测出针对 SARS-CoV-2 的抗体。此外,还询问了参与者有关 COVID-19 发生的潜在职业和环境风险因素。结果在拉林科纳达接受检测的 159 名居民中,48.4%[95% 置信区间:40.5-56.4] 对 SARS-CoV-2 呈血清阳性。在过去 6 个月中至少出现过一种与 COVID-19 相符的症状仍然是与 SARS-CoV-2 血清阳性相关的唯一重要因素(调整后的几率比:3.27;[95% 置信区间:1.70-6.44];P 结论:SARS-CoV-2 血清阳性率较高的原因是在过去 6 个月中至少出现过一种与 COVID-19 相符的症状:在这一高原小样本中观察到的高SARS-CoV-2血清阳性率不支持高海拔对COVID-19传播的保护作用,并证明了它在易感人群中的广泛传播。临床试验注册号:NCT04604249:NCT04604249。
High-Altitude Environment and COVID-19: SARS-CoV-2 Seropositivity in the Highest City in the World.
Champigneulle, Benoit, Ivan Hancco, Richard Renan, Stéphane Doutreleau, Emeric Stauffer, Aurélien Pichon, Julien V. Brugniaux, Hélène Péré, Pierre Bouzat, David Veyer, and Samuel Verges. High-altitude environment and COVID-19: SARS-CoV-2 seropositivity in the highest city in the world. High Alt Med Biol. 22: 000-000, 2021. Background: A reduced coronavirus disease 2019 (COVID-19) diffusion has been suggested in high-altitude areas but remained questionable. Aims of this study were to estimate severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) seropositivity as well as the risk factors associated in La Rinconada, the highest city in the world (5,100-5,300 m), a gold-mining town located in southeastern Peru where >50,000 dwellers live in precarious sanitary conditions. Materials and Methods: We performed a cross-sectional study during a 1-week period in October 2020, using point-of-care lateral flow serological assays allowing detection of antibodies directed against SARS-CoV-2 among voluntary dwellers in La Rinconada. Participants were also questioned about potential occupational and environmental risk factors of COVID-19 occurrence. Results: In a sample of 159 dwellers tested in La Rinconada, 48.4% [95% confidence interval, CI: 40.5-56.4] were seropositive for the SARS-CoV-2. Occurrence of at least one symptom compatible with the COVID-19 over the past 6 months remained the only significant factor associated with SARS-CoV-2 seropositivity (adjusted odds ratio: 3.27; [95% CI: 1.70-6.44]; p < 0.001). Conclusions: The high rate of SARS-CoV-2 seropositivity observed in this small sample of highlanders does not support a protective effect of high-altitude against the COVID-19 spread and demonstrates its large dissemination in vulnerable populations. Clinical Trial Registration number: NCT04604249.
期刊介绍:
High Altitude Medicine & Biology is the only peer-reviewed journal covering the medical and biological issues that impact human life at high altitudes. The Journal delivers critical findings on the impact of high altitude on lung and heart disease, appetite and weight loss, pulmonary and cerebral edema, hypertension, dehydration, infertility, and other diseases. It covers the full spectrum of high altitude life sciences from pathology to human and animal ecology.