载抗生素骨水泥中液体阿米卡星的安全性和耐受性-一个病例系列。

IF 1.8 Q3 INFECTIOUS DISEASES Journal of Bone and Joint Infection Pub Date : 2021-04-26 eCollection Date: 2021-01-01 DOI:10.5194/jbji-6-147-2021

Don Bambino Geno Tai, Nathan J Brinkman, Omar Abu Saleh, Douglas R Osmon, Matthew P Abdel, Christina G Rivera

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摘要

大剂量液体抗生素在骨水泥中并不常见。我们提出了一个病例系列的患者，其中高达16 mL的液体阿米卡星(250 mg mL - 1)被成功地纳入骨水泥治疗假体周围关节感染。我们没有观察到明确归因于其使用的药物不良反应。

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Safety and tolerability of liquid amikacin in antibiotic-loaded bone cement - a case series.

High-dose liquid antibiotics are uncommon in bone cement. We present a case series of patients in which up to 16 mL of liquid amikacin (250 mg mL $^{- 1}$ ) was successfully incorporated into bone cement to treat periprosthetic joint infections. We did not observe adverse drug reactions definitively attributed to its use.

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