头孢唑林和利福平治疗期间凝血功能障碍:罕见但危险。

IF 1.8 Q3 INFECTIOUS DISEASES Journal of Bone and Joint Infection Pub Date : 2021-04-01 eCollection Date: 2021-01-01 DOI:10.5194/jbji-6-131-2021

Ines Kouki, Clémence Montagner, Wladimir Mauhin, Jonathan London, Thierry Lazard, Sylvie Grimbert, Valérie Zeller, Olivier Lidove

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引用次数: 3

摘要

我们描述了一个79岁的男子与脊椎椎间盘炎和未知病原体，治疗头孢唑林和利福平。他出现了大量的消化系统出血。凝血酶原时间延长，维生素k依赖性凝血因子严重缺乏。在使用头孢唑林和利福平期间可发生严重出血。在开头孢唑林-利福平处方前应评估这种缺陷，并监测凝血酶原时间。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Coagulation disorders during treatment with cefazolin and rifampicin: rare but dangerous.

We describe a 79-year-old man with spondylodiscitis and unknown pathogen, treated with cefazolin and rifampicin. He developed a massive digestive hemorrhage. Prothrombin time was prolonged with severe vitamin-K-dependent clotting-factor deficiency. Severe bleeding can occur during cefazolin and rifampicin use. This deficiency should be assessed before prescribing cefazolin-rifampicin and prothrombin time monitored.

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