早发重度子痫前期孕妇体内 S100B 蛋白的临床意义。

IF 1.2 4区 医学 Q3 OBSTETRICS & GYNECOLOGY Ginekologia polska Pub Date : 2024-01-01 Epub Date: 2021-06-09 DOI:10.5603/GP.a2021.0126
Jinxia Wu, Xiaoqi Sheng, Shaoming Zhou, Chaoying Fang, Yulin Song, Hua Wang, Zhengjun Jia, Xiaozhou Jia, Yiping You
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引用次数: 0

摘要

目的:子痫前期是最可怕的妊娠并发症之一,可迅速发展为严重并发症,如母亲和胎儿死亡。目前,子痫前期的主要病因仍存在争议。本文旨在探讨S100B蛋白(一种Ca2+传感蛋白)在早发重度子痫前期中的临床意义:材料:本研究纳入了9名早发重度子痫前期孕妇(研究组)和13名健康孕妇(对照组)。采用酶联免疫吸附试验(ELISA)和表面等离子体共振成像(SPRi)方法检测羊水、母血和脐带血中的 S100B 水平。通过接收者操作特征曲线(ROC)分析评估了S100B对早发重度子痫前期的诊断价值:研究组母体血液和羊水中的 S100B 水平均高于对照组(P < 0.05)。ROC曲线分析显示,SPRi法(SPRi-S100B)检测的S100B临界值为181 ng/mL,灵敏度为100%,特异性为84.6%,Youden指数为0.846,与ELISA法(ELISA-S100B)相比具有更好的临床意义和诊断价值:结论:通过SPRi检测母体血液中的S100B水平可预示早期重度子痫前期和围产期脑损伤。
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Clinical significance of S100B protein in pregnant woman with early- onset severe preeclampsia.

Objectives: Preeclampsia is one of the most feared complications of pregnancy, which can progress rapidly to serious complications such as death of both mother and fetus. To present, the leading cause of preeclampsia is still debated. The purpose of this article was to explore the clinical significance of S100B protein, a kind of Ca2+ -sensor protein, in the early-onset severe preeclampsia.

Material and methods: Nine pregnant women with early-onset severe preeclampsia (the study group) and 13 healthy pregnant women (the control group) were included in this study. The level of S100B in the amniotic fluid, maternal blood, and umbilical cord blood were detected by enzyme-linked immunosorbent assay (ELISA) and surface plasmon resonance imaging (SPRi) methods. Diagnostic values of S100B for early-onset severe preeclampsia were assessed by Receiver Operating Characteristic (ROC) curve analysis.

Results: The levels of S100B in maternal blood and amniotic fluid in the study group were higher than those in the control group (p < 0.05). ROC curve analysis showed that S100B detected by SPRi method (SPRi-S100B) showed a cut-off level of 181 ng/mL with sensitivity of 100%, a specificity of 84.6%, and a Youden index of 0.846 in the maternal blood, which had better clinical significance and diagnostic value (at than that detected by ELISA (ELISA-S100B).

Conclusions: The levels of S100B detected by SPRi in maternal blood can indicate early-onset severe preeclampsia and perinatal brain injury.

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来源期刊
Ginekologia polska
Ginekologia polska OBSTETRICS & GYNECOLOGY-
CiteScore
2.00
自引率
15.40%
发文量
317
审稿时长
4-8 weeks
期刊介绍: Ginekologia Polska’ is a monthly medical journal published in Polish and English language. ‘Ginekologia Polska’ will accept submissions relating to any aspect of gynaecology, obstetrics and areas directly related. ‘Ginekologia Polska’ publishes original contributions, comparative works, case studies, letters to the editor and many other categories of articles.
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