前列腺素EP4受体在犬骨肉瘤中的基因表达分析。

IF 1.1 4区农林科学 Q2 Veterinary Canadian journal of veterinary research = Revue canadienne de recherche veterinaire Pub Date : 2021-01-01

Margaret L Musser, Austin K Viall, Rachel L Phillips, Jesse M Hostetter, Chad M Johannes

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引用次数: 0

摘要

在许多人类癌症中，前列腺素受体EP4 (EP4R)的表达与恶性肿瘤的发展和不良预后相关。EP4R在犬肿瘤中的表达尚未被评估。本研究的目的是表征EP4R信使RNA (mRNA)在犬骨肉瘤(OSA)中的表达。采用RNA原位杂交技术(RNAscope)检测EP4R基因的表达。在所有评估的犬OSA样本中，EP4R普遍呈阳性表达。EP4R基因在OSA组织样本中的表达明显高于正常鼻甲骨，可能与犬OSA的发病机制有关。

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Analysis of gene expression of prostaglandin EP4 receptor in canine osteosarcoma.

In many human cancers, the expression of the prostaglandin receptor EP4 (EP4R) is associated with the development of malignancy and a poor prognosis. The expression of EP4R has not yet been evaluated in canine tumors. The objective of this study was to characterize the messenger RNA (mRNA) expression of EP4R in canine osteosarcoma (OSA). Gene expression of EP4R was evaluated using RNA in-situ hybridization (RNAscope). In all canine OSA samples evaluated, strong universal positive expression of EP4R was identified. Gene expression was significantly higher in OSA tissue samples than in normal nasal turbinate bone, possibly implicating EP4R in the pathogenesis of canine OSA.

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来源期刊

Canadian journal of veterinary research = Revue canadienne de recherche veterinaire 农林科学-兽医学

CiteScore

1.80

自引率

0.00%

发文量

审稿时长

>24 weeks

期刊介绍： The Canadian Journal of Veterinary Research, published by the Canadian Veterinary Medical Association, is Canada''s only veterinary research publication. This quarterly peer-reviewed online-only journal has earned a wide international readership through the publishing of high quality scientific papers in the field of veterinary medicine. The Journal publishes the results of original research in veterinary and comparative medicine.