在社区样本中，水烟吸烟与动脉硬度和波反射的关系。

IF 1.8 4区医学 Blood Pressure Pub Date : 2021-10-01 Epub Date: 2021-07-08 DOI:10.1080/08037051.2021.1947778

Hassan A Chami, Hussain Isma'eel, Gary F Mitchel, Hani Tamim, Maha Makki, Adel Berbari, Ahmad Al Mulla

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引用次数: 2

摘要

目的:将水烟与心血管疾病联系起来的证据是有限的。我们评估了水烟吸烟(WPS)与动脉硬度和波反射(通过增强压力(AP)、增强指数(AIx)和颈-股脉波速度(CFPWV)测量)的关系，这是心血管疾病的有效预测因子。材料和方法:以社区为基础的横断面研究，包括205例独家水烟吸烟者和199例匹配的35岁及以上的不吸烟者(平均年龄51.7±8.9岁，36%为女性)。吸烟及其程度通过有效问卷和尿可替宁水平进行评估。使用血压计测定CFPWV、AP、AIx (AP/主动脉脉压)和心率调整后的AIx (AIx@75)，并在吸烟者和非吸烟者之间进行比较，使用线性回归对可能的混杂因素进行调整，评估WPS与血压计测量的相关性。结果:水烟吸烟者和非吸烟者的平均年龄和性别分布相似。与不吸烟者相比，水烟吸烟者的调整AP明显更高(分别为10.5±3.9 vs 9.4±3.9 mmHg);p = 0.01), AIx(分别为28.1±8.4和25.7±8.5%;p = 0.01)和AIx@75(分别为24.2±8.7和21.8±8.9%;p = 0.01)。AIx和WPS程度显著相关,通过测量大量的给水管抽/天(β= 1.04 /给水管,95%置信区间ci:[0.50 - -1.58]),期间给水管吸烟(β= 0.77 / 10年期公债,95%置信区间ci:[0.16 - -1.38]),他们的产品在waterpipe-years(β= 0.30 / 10-waterpipe-year, 95%置信区间ci:[0.12 - -0.47])和血浆可替宁(β= 0.56/100 ng / ml, 95%置信区间ci:[0.14 - -0.98]),调整可能的混杂因素,所以是美联社和AIx@75。然而，CFPWV与水烟吸烟无关。结论:在以社区为基础的样本中，排他性WPS及其程度与AIx和AP的剂量依赖性增加相关，考虑到其他危险因素，提示水烟吸烟者心血管疾病风险增加。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The association of waterpipe smoking with arterial stiffness and wave reflection in a community-based sample.

Purpose: The evidence linking waterpipe smoking to cardiovascular disease is limited. We evaluated the association of waterpipe smoking (WPS) with arterial stiffness and wave reflection measured by augmentation pressure (AP), augmentation index (AIx), and carotid-femoral pulse wave velocity (CFPWV), which are validated predictors of cardiovascular disease.

Materials and methods: Community-based, cross-sectional study including 205 exclusive waterpipe smokers and 199 matched never-smokers aged 35 years or older (mean age 51.7 ± 8.9 years, 36% females). Smoking and its extent were assessed using a validated questionnaire and urine cotinine levels. CFPWV, AP, AIx (AP/aortic pulse pressure) and heart rate adjusted AIx (AIx@75) were determined using tonometry and compared between smokers and non-smokers, and the association of WPS with tonometry measures was assessed using linear regression adjusting for possible confounders.

Results: Waterpipe smokers and non-smokers had similar mean age and sex distribution. Compared to non-smokers, waterpipe smokers had significantly higher adjusted AP (10.5 ± 3.9 vs. 9.4 ± 3.9 mmHg respectively; p = 0.01), AIx (28.1 ± 8.4 vs. 25.7 ± 8.5% respectively; p = 0.01) and AIx@75 (24.2 ± 8.7 vs. 21.8 ± 8.9% respectively; p = 0.01). AIx was significantly associated with WPS extent, measured by a number of waterpipe smoked/day (β = 1.04/waterpipe, 95%CI:[0.50-1.58]), duration of waterpipe smoking (β = 0.77/10-years, 95%CI:[0.16-1.38]), their products in waterpipe-years (β = 0.30/10-waterpipe-year, 95%CI:[0.12-0.47]) and plasma cotinine (β = 0.56/100 ng/ml, 95%CI:[0.14-0.98]), adjusting for possible confounders, and so were AP and AIx@75. CFPWV however, was not associated with waterpipe smoking.

Conclusion: In a community-based sample, exclusive WPS and its extent were associated with a dose-dependent increase in AIx and AP, accounting for other risk factors, suggesting that waterpipe smokers are at increased risk of cardiovascular disease.

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来源期刊

Blood Pressure Medicine-Cardiology and Cardiovascular Medicine

CiteScore

3.20

自引率

5.60%

发文量

期刊介绍： For outstanding coverage of the latest advances in hypertension research, turn to Blood Pressure, a primary source for authoritative and timely information on all aspects of hypertension research and management. Features include: • Physiology and pathophysiology of blood pressure regulation • Primary and secondary hypertension • Cerebrovascular and cardiovascular complications of hypertension • Detection, treatment and follow-up of hypertension • Non pharmacological and pharmacological management • Large outcome trials in hypertension.