两种Co(II)配位聚合物:磁性和对慢性硬膜下血肿的应用价值。

IF 1.8 4区 化学 Q3 POLYMER SCIENCE Designed Monomers and Polymers Pub Date : 2021-06-28 eCollection Date: 2021-01-01 DOI:10.1080/15685551.2021.1935535
Jing-Sen Chen, Sheng-Long Cao, Hai-Ying Hu, Juan Shen, Yu-Jun Qi
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引用次数: 0

摘要

本实验采用混合配体合成方法,在不同羧基配体的辅助下,通过1,3-双(1-咪唑)苯(mbib)和Co(II)盐的反应,成功合成了两种含Co(II)的配位聚合物(CPs),其化学式为[Co3(opda)3(mbib)4(H2O)4]·2H2O (1, H2opda为1,2-苯二乙酸)和[Co(mpda)(mbib)]·H2O (2, H2mpda为1,3-苯二乙酸)。两种化合物的磁性能表明相邻金属离子之间存在反铁磁耦合。对其治疗慢性硬膜下血肿的疗效进行评价,并对其作用机制进行研究。首先,在复方治疗前,已产生慢性硬膜下血肿。采用酶联免疫吸附法检测血肿胶囊中抗炎细胞因子和促炎细胞因子水平。此外,用细胞计数试剂盒-8测定化合物1和2对正常人细胞的细胞毒性。综上所述,我们证明化合物1降低了血肿胶囊中促炎细胞因子的含量,增加了抗炎细胞因子的含量,其作用强于化合物2。化合物1和2对人体正常细胞均无细胞毒性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Two Co(II) coordination polymers: magnetic properties and application values against chronic subdural hematoma.

In this current experiment, by applying the mixed-ligand synthesis method, two coordination polymers (CPs) containing Co(II) were created triumphantly with reaction between 1,3-bis(1-imidazoly)benzene (mbib) and Co(II) salts with the aid of diverse carboxylic ligands, and their chemical formulae are [Co3(opda)3(mbib)4(H2O)4]·2H2O (1, H2opda is 1,2-phenylenediacetic acid) and [Co(mpda)(mbib)]·H2O (2, H2mpda is 1,3-phenylenediacetic acid). The two compounds' magnetic performances suggest that between the adjacent metal ions, there present the antiferromagnetic coupling. The evaluation of their treatment activity against chronic subdural hematoma was carried out and the relevant mechanism was studied simultaneously. Firstly, before the treatment of compound, the chronic subdural hematoma was generated. Furthermore, the enzyme-linked immunosorbent assay detection kit was implemented and in hematoma capsule, the anti-inflammatory cytokines level and pro-inflammatory cytokines level was detected. Additionally, the cytotoxicity of compounds 1 and 2 on the normal human cells was determined with Cell Counting Kit-8 assay. Above all, we proved compound 1 decreased the pro-inflammatory cytokines content and increased the anti-inflammatory cytokines content in the hematoma capsule, which is much stronger than that of compound 2. Both compounds 1 and 2 showed no cytotoxicity on the normal human cells.

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来源期刊
Designed Monomers and Polymers
Designed Monomers and Polymers 化学-高分子科学
CiteScore
3.30
自引率
0.00%
发文量
28
审稿时长
2.1 months
期刊介绍: Designed Monomers and Polymers ( DMP) publishes prompt peer-reviewed papers and short topical reviews on all areas of macromolecular design and applications. Emphasis is placed on the preparations of new monomers, including characterization and applications. Experiments should be presented in sufficient detail (including specific observations, precautionary notes, use of new materials, techniques, and their possible problems) that they could be reproduced by any researcher wishing to repeat the work. The journal also includes macromolecular design of polymeric materials (such as polymeric biomaterials, biomedical polymers, etc.) with medical applications. DMP provides an interface between organic and polymer chemistries and aims to bridge the gap between monomer synthesis and the design of new polymers. Submssions are invited in the areas including, but not limited to: -macromolecular science, initiators, macroinitiators for macromolecular design -kinetics, mechanism and modelling aspects of polymerization -new methods of synthesis of known monomers -new monomers (must show evidence for polymerization, e.g. polycondensation, sequential combination, oxidative coupling, radiation, plasma polymerization) -functional prepolymers of various architectures such as hyperbranched polymers, telechelic polymers, macromonomers, or dendrimers -new polymeric materials with biomedical applications
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