{"title":"血栓性微血管病的传统和新型抗癌疗法之间的联系。","authors":"Carmen E Cervantes, Sam Kant, Mohamed G Atta","doi":"10.2174/1872312814666210716141633","DOIUrl":null,"url":null,"abstract":"BACKGROUND\nKidney disease associated with cancer and anti-cancer therapies has been increasingly recognized in the field of Onco-nephrology. In particular, drug-induced nephrotoxicity has necessary implications since most chemotherapeutic agents have nephrotoxic potential. Also, standard creatinine clearance methods used to measure kidney function have been questioned in cancer patients due to factors like low muscle mass and poor nutritional status. Overestimations of the glomerular filtration rate not only increase the nephrotoxic potential of different agents but also can further limit the use of first-line therapies.\n\n\nOBJECTIVE\nThis review covers drug-induced thrombotic microangiopathy explicitly. It has two pathophysiologic mechanisms, including immune or idiosyncratic reactions and non-immune or dose-dependent ones.\n\n\nCONCLUSION\nAs novel cancer therapies are developed, it is paramount to understand better conventional and novel chemotherapeutic agents and their role in kidney disease.","PeriodicalId":11339,"journal":{"name":"Drug metabolism letters","volume":"14 2","pages":"97-105"},"PeriodicalIF":0.0000,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"The Link Between Conventional and Novel Anti-Cancer Therapeutics with Thrombotic Microangiopathy.\",\"authors\":\"Carmen E Cervantes, Sam Kant, Mohamed G Atta\",\"doi\":\"10.2174/1872312814666210716141633\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"BACKGROUND\\nKidney disease associated with cancer and anti-cancer therapies has been increasingly recognized in the field of Onco-nephrology. In particular, drug-induced nephrotoxicity has necessary implications since most chemotherapeutic agents have nephrotoxic potential. Also, standard creatinine clearance methods used to measure kidney function have been questioned in cancer patients due to factors like low muscle mass and poor nutritional status. Overestimations of the glomerular filtration rate not only increase the nephrotoxic potential of different agents but also can further limit the use of first-line therapies.\\n\\n\\nOBJECTIVE\\nThis review covers drug-induced thrombotic microangiopathy explicitly. It has two pathophysiologic mechanisms, including immune or idiosyncratic reactions and non-immune or dose-dependent ones.\\n\\n\\nCONCLUSION\\nAs novel cancer therapies are developed, it is paramount to understand better conventional and novel chemotherapeutic agents and their role in kidney disease.\",\"PeriodicalId\":11339,\"journal\":{\"name\":\"Drug metabolism letters\",\"volume\":\"14 2\",\"pages\":\"97-105\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Drug metabolism letters\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2174/1872312814666210716141633\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Drug metabolism letters","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/1872312814666210716141633","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
The Link Between Conventional and Novel Anti-Cancer Therapeutics with Thrombotic Microangiopathy.
BACKGROUND
Kidney disease associated with cancer and anti-cancer therapies has been increasingly recognized in the field of Onco-nephrology. In particular, drug-induced nephrotoxicity has necessary implications since most chemotherapeutic agents have nephrotoxic potential. Also, standard creatinine clearance methods used to measure kidney function have been questioned in cancer patients due to factors like low muscle mass and poor nutritional status. Overestimations of the glomerular filtration rate not only increase the nephrotoxic potential of different agents but also can further limit the use of first-line therapies.
OBJECTIVE
This review covers drug-induced thrombotic microangiopathy explicitly. It has two pathophysiologic mechanisms, including immune or idiosyncratic reactions and non-immune or dose-dependent ones.
CONCLUSION
As novel cancer therapies are developed, it is paramount to understand better conventional and novel chemotherapeutic agents and their role in kidney disease.
期刊介绍：
Drug Metabolism Letters publishes letters and research articles on major advances in all areas of drug metabolism and disposition. The emphasis is on publishing quality papers very rapidly by taking full advantage of the Internet technology both for the submission and review of manuscripts. The journal covers the following areas: In vitro systems including CYP-450; enzyme induction and inhibition; drug-drug interactions and enzyme kinetics; pharmacokinetics, toxicokinetics, species scaling and extrapolations; P-glycoprotein and transport carriers; target organ toxicity and interindividual variability; drug metabolism and disposition studies; extrahepatic metabolism; phase I and phase II metabolism; recent developments for the identification of drug metabolites.
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