利用人源化小鼠促进我们对艾滋病病毒合并感染和神经系统疾病的了解。

IF 2.7 3区 医学 Q3 VIROLOGY Retrovirology Pub Date : 2021-06-16 DOI:10.1186/s12977-021-00559-z
Janice J Endsley, Matthew B Huante, Kubra F Naqvi, Benjamin B Gelman, Mark A Endsley
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引用次数: 0

摘要

人源化小鼠已成为艾滋病研究的重要工作模型。人类免疫系统在免疫缺陷小鼠品系中的发展为艾滋病发病机制和免疫功能障碍方面的新基础研究提供了帮助。小动物的特点有利于开发难以在临床群组中研究的临床干预措施,并避免了使用非人灵长类动物的高成本和监管负担。该模型还克服了艾滋病毒对人类免疫细胞的宿主限制,这种限制限制了与艾滋病毒感染者的重要合并感染相关的发现和转化研究。在这篇综述中,我们将重点介绍在人源化小鼠中模拟艾滋病病毒细菌和病毒合并感染的最新进展,尤其是神经系统疾病以及结核分枝杆菌和艾滋病病毒合并感染。还进一步讨论了当前和未来的合并感染模型在解决重要临床和研究问题方面的应用。
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Advancing our understanding of HIV co-infections and neurological disease using the humanized mouse.

Humanized mice have become an important workhorse model for HIV research. Advances that enabled development of a human immune system in immune deficient mouse strains have aided new basic research in HIV pathogenesis and immune dysfunction. The small animal features facilitate development of clinical interventions that are difficult to study in clinical cohorts, and avoid the high cost and regulatory burdens of using non-human primates. The model also overcomes the host restriction of HIV for human immune cells which limits discovery and translational research related to important co-infections of people living with HIV. In this review we emphasize recent advances in modeling bacterial and viral co-infections in the setting of HIV in humanized mice, especially neurological disease, and Mycobacterium tuberculosis and HIV co-infections. Applications of current and future co-infection models to address important clinical and research questions are further discussed.

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来源期刊
Retrovirology
Retrovirology 医学-病毒学
CiteScore
5.80
自引率
3.00%
发文量
24
审稿时长
>0 weeks
期刊介绍: Retrovirology is an open access, online journal that publishes stringently peer-reviewed, high-impact articles on host-pathogen interactions, fundamental mechanisms of replication, immune defenses, animal models, and clinical science relating to retroviruses. Retroviruses are pleiotropically found in animals. Well-described examples include avian, murine and primate retroviruses. Two human retroviruses are especially important pathogens. These are the human immunodeficiency virus, HIV, and the human T-cell leukemia virus, HTLV. HIV causes AIDS while HTLV-1 is the etiological agent for adult T-cell leukemia and HTLV-1-associated myelopathy/tropical spastic paraparesis. Retrovirology aims to cover comprehensively all aspects of human and animal retrovirus research.
期刊最新文献
A gut check: understanding the interplay of the gastrointestinal microbiome and the developing immune system towards the goal of pediatric HIV remission. High level of genomic divergence in orf-I p12 and hbz genes of HTLV-1 subtype-C in Central Australia. In situ analysis of neuronal injury and neuroinflammation during HIV-1 infection. Comparative analysis of retroviral Gag-host cell interactions: focus on the nuclear interactome. Retroviral PBS-segment sequence and structure: Orchestrating early and late replication events.
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