家族性与散发性非髓样甲状腺癌(NMTC)较长时间达到良好的治疗反应:一项匹配的病例对照研究

IF 2.1 Q3 ENDOCRINOLOGY & METABOLISM International Journal of Endocrinology and Metabolism Pub Date : 2021-05-11 eCollection Date: 2021-04-01 DOI:10.5812/ijem.108781
Susan Shafiei, Mehrdokht Sadrolodabaei, Atena Aghaei, Narjess Ayati, Samira Zare Namdar, Donya Hemati, Seyed Rasoul Zakavi
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引用次数: 0

摘要

背景:家族性非髓样甲状腺癌(NMTC)被认为比非家族性甲状腺癌更具侵袭性,需要更频繁的治疗。目的:本配对病例对照研究旨在比较家族性和散发性NMTC配对病例对照组之间的治疗反应。方法:这是一项回顾性研究,对家族性NMTC患者(至少有一个其他一级亲属参与)进行手术治疗,然后进行放射性碘治疗(RIT),而不考虑其家族起源。比较家族性NMTC与年龄、性别和TNM分期匹配的非家族性NMTC(对照组)对治疗的反应。RIT后1年和2年评估对治疗的反应,并确定达到良好反应的时间。结果:2944例NMTC患者中,81例(2.75%)为家族性NMTC。我们比较了66例家族性NMTC和66例散发性NMTC患者。患者和对照组在首次甲状腺球蛋白、初始和累积碘剂量以及附加治疗(附加手术和放疗)方面无显著差异。尽管病例组和对照组在1年和2年的治疗反应上没有显著差异,但家族性NMTC患者需要更多的时间才能达到优异的疗效(26.7±24.9个月比15.9±9.0个月,P = 0.01)。有两个或两个以上亲属的家族性NMTC患者之间无显著差异。结论:我们的研究表明,如果家族性NMTCs患者与非家族性NMTCs患者采用相同的治疗方法,即使他们只有一个其他相关亲属,获得良好反应的时间也会明显更长。
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Longer Time to Reach Excellent Response to Treatment in Familial Versus Sporadic Non-medullary Thyroid Cancer (NMTC): A Matched Case-Control Study.

Background: Familial non-medullary thyroid cancer (NMTC) are supposed to be more aggressive and require more frequent treatment compared to non-familial thyroid cancer.

Objectives: This matched case-control study aimed to compare the response to treatment between the matched case-control groups of familial and sporadic NMTC.

Methods: This is a retrospective study in patients with familial NMTC (at least one other first-degree relative involved) who were treated with surgery, followed by radio-iodine therapy (RIT) without consideration of its familial origin. Response to treatment was compared between familial NMTC and age, sex, and TNM stage-matched non-familial NMTC (control group). Response to treatment was assessed one and two years after RIT, and time to excellent response was identified.

Results: Out of 2,944 NMTC patients, 81 (2.75%) patients had familial NMTC. We compared 66 patients with familial NMTC and 66 sporadic NMTC patients. There was no significant difference in first thyroglobulin, initial and accumulative iodine dose, and additional treatments (additional surgery and radiotherapy) between patients and controls. Although no significant difference was noted in one and two years' responses to treatment between the case and control groups, familial NMTC patients required more time to achieve excellent response (26.7 ± 24.9 versus 15.9 ± 9.0 months, P = 0.01). No significant difference was noted between familial NMTC patients with two or more than two involved relatives.

Conclusions: Our study showed that if patients with familial NMTCs were treated in the same way as non-familial patients, the time to excellent response would be significantly longer, even when they have only one other involved relative.

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来源期刊
CiteScore
3.10
自引率
4.80%
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期刊介绍: The aim of the International Journal of Endocrinology and Metabolism (IJEM) is to increase knowledge, stimulate research in the field of endocrinology, and promote better management of patients with endocrinological disorders. To achieve this goal, the journal publishes original research papers on human, animal and cell culture studies relevant to endocrinology.
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