血液透析患者的脆弱表型及其与骨矿物质紊乱、炎症和营养生化指标的关系。

IF 1.6 Q2 MEDICINE, GENERAL & INTERNAL Romanian Journal of Internal Medicine Pub Date : 2022-03-17 Print Date: 2022-03-01 DOI:10.2478/rjim-2021-0030
Alma Mutevelić-Turković, Halima Resić, Badema Čengić Roljić, Amela Dervišević, Amela Bećiragić
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引用次数: 3

摘要

简介:虚弱是一种对身体压力的脆弱性增加的状态。它是常见的终末期肾病(ESRD)患者谁是血液透析(HD)。本研究的目的是分析HD患者中脆弱表型的存在,并评估其与不同生化标志物的相互关系。方法:虚弱评估采用了Fried等人的虚弱表型,如果满足以下三个标准:非故意体重减轻、自我报告的疲惫、虚弱、缓慢的步行速度和低体力活动,则报告虚弱。281例HD患者中,126例体弱,58例体弱前期(满足两个标准),其余研究人群健康(97例)。计算所有患者的BMI,并采集静脉血,测定骨碱性磷酸酶(BAP)、磷酸盐(P)、钾(K)、c反应蛋白(CRP)和白蛋白的实验室参数。结果:HD治疗超过60个月的患者有更多的虚弱特征。(p = 0.019)。衰弱评分与BAP呈正相关(rho = 0.189;p = 0.001), CRP (rho = 0.233;P < 0.001),虚弱评分与白蛋白呈显著负相关(rho = - 0.218;p < 0.001)和K (rho = - 0.198;P = 0.001)。结论:虚弱与矿物质骨紊乱、炎症和营养标志物的关联表明,这些参数在间接评估HD患者虚弱表型中的重要性。
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The frailty phenotype in hemodialysis patients and its association with biochemical markers of mineral bone disorder, inflammation and nutrition.

Introduction: Frailty is a state of increased vulnerability to physical stressors. It is common in patients with end-stage renal disease (ESRD) who are on hemodialysis (HD).The aim of this study was to analyze the presence of frailty phenotype among HD patients and to evaluate their interrelationship with different biochemical markers.Methods: For the frailty assessment the Frailty Phenotype by Fried et al. was used, where frailty was reported if three of the following criteria were met: unintentional weight loss, self-reported exhaustion, weakness, slow walking speed and low physical activity. From 281 HD patients, 126 patients were frail, 58 were pre-frail (two criteria were met) and the rest of the study population were robust (97 patients). BMI was calculated for all patients and venous blood samples were taken to determine laboratory parameters for bone alkaline phosphatase (BAP), phosphate (P), potassium (K), C-reactive protein (CRP) and albumin.Results: Patients who were on HD longer than 60 months have more characters of frailty. (p=0.019). A statistically significant positive correlations between frailty score and BAP (rho = 0.189; p = 0.001), and CRP (rho = 0.233; p < 0.001) were observed, and significant negative correlations between frailty score and albumin (rho = - 0.218; p < 0.001) and K (rho = - 0.198; p = 0.001).Conclusions: The associations of frailty with markers of mineral bone disorder, inflammation and nutrition indicate the importance of these parameters in the indirect assessment of the frailty phenotype in HD patients.

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来源期刊
Romanian Journal of Internal Medicine
Romanian Journal of Internal Medicine MEDICINE, GENERAL & INTERNAL-
CiteScore
3.20
自引率
5.30%
发文量
35
审稿时长
15 weeks
期刊介绍: Romanian Journal of Physics is a journal publishing physics contributions on the following themes: •Theoretical Physics & Applied Mathematics •Nuclear Physics •Solid State Physics & Materials Science •Statistical Physics & Quantum Mechanics •Optics •Spectroscopy •Plasma & Lasers •Nuclear & Elementary Particles Physics •Atomic and Molecular Physics •Astrophysics •Atmosphere and Earth Science •Environment Protection
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